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Table 1 IC50 value of aqueous and methanol extracts of Piptadeniastrum africanum on human whole blood evaluated by luminol and/or lucigenin amplified chemiluminescence

From: Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund’s adjuvant-induced arthritis in rats

  Oxidative burst (IC50 μg/ml) T-cells proliferation (IC50 μg/ml) Cytotoxicity on 3T3 Cells (IC50 μg/ml)
Luminol and Zymosan Lucigenin and PMA   
WB PMNs MQ WB PMNs MQ   
Aqueous extract 10.04 ± 0.31 8.68 ± 0.52 11.64 ± 0.29 8.59 ± 0.12 5.74 ± 0.38 11.85 ± 0.36 29.30 ± 0.36 78.60 ± 0.35
Methanol extract 4.02 ± 0.10 2.29 ± 0.10 2.85 ± 0.12 4.89 ± 0.28 2.96 ± 0.07 2.80 ± 0.02 <1 6.13 ± 0.25
Ibuprofen 13.00 ± 0.30 12.97 ± 0.23 13.93 ± 0.52 13.73 ± 0.58 13.69 ± 0.61 14.30 ± 0.49 - -
Prednisolone - - - - - - <3.1 -
Cyclohexamide - - - - - - - 0.1 ± 0.13
  1. The IC50 values are presented as mean ± SD of triplicates. Where WB whole blood, PMNs polymorphonuclear leukocytes, MQ mice peritoneal macrophages