Fig. 8

Histopathological analysis of ankle joints stained with H&E. a Healthy control shows normal structure with small joint space; b Arthritic control which shows very large joint space (1), severe hyperplasia (2), granulomas (3), cells infiltration (4) and erosion (5); indomethacin 5 mg/kg treated (c), aqueous extract 400 mg/kg treated (d) and methanol extract 400 mg/kg treated (e) show a decrease in joint space (1) and a reduction of cells infiltration