Fig. 4

Inhibition of human breast tumor growth by TAM, BD, and TAM and BD combination in vivo. a Xenograft experiments were performed as described in Materials and Methods. During the treatment period, tumor sizes were measured 3 times per week. Statistical analysis by ANOVA and Holm-Sidak. *P < 0.05: control vs TAM, control vs. BD, control vs, BD + TAM. (n = 16-24 tumors per group). b Tumor sizes at the beginning (Day1) and the end (Day 29) of the treatment. Statistical analysis by ANOVA and Holm-Sidak. Different letters above bars indicate significant differences P < 0.05. Box plots represent 5th/10th percentiles, mean (white dotted line), horizontal bars represent median values, whiskers indicate minimum to maximum values and triangles represent outliers. c At the end of the experiment (Day 29), tumors were harvested and weighed. Statistical analysis by ANOVA and Holm-Sidak. Different letters above bars indicate significant differences P < 0.05. Box plots represent 5th/10th percentiles, mean (white dotted line), horizontal bars represent median values, whiskers indicate minimum to maximum values and triangles represent outliers