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Table 1 Cytotoxicity and direct antiviral activity against HSV-2 of the 50% ethanolic extract prepared from fruits of T. chebula, chebulagic acid, chebulinic acids and acyclovir in Vero cells

From: Anti-HSV-2 activity of Terminalia chebula Retz extract and its constituents, chebulagic and chebulinic acids

Test compounds aCC50 (μg/ml) bIC50 (μg/ml)
T. chebula 50% ethanolic extract 409.71 ± 47.70 0.01 ± 0.0002
Chebulagic acid >200c 1.41 ± 0.51
Chebulinic acid >200c 0.06 ± 0.002
Acyclovir 351.85 ± 48.80 29.04 ± 1.04
  1. Values in this table represent the mean ± SE of four independent experiments performed in duplicate
  2. aCC50 was the concentration that showed viability of 50% of the Vero cells
  3. bIC50 was the concentration that inhibited 50% of HSV-2 activity in direct anti- viral activity assay using Vero cells as host
  4. c > 95% cells were viable at 200 μg/ml
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