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Table 1 The effects of A. rugosa extracts, acacetin and tilianin on APTT, PT, TT, and FIB in vitro (‾x ± s)

From: Chemical constituents and coagulation activity of Agastache rugosa

Groups APTT (S) PT (S) TT (S) FIB (g/L)
Blank 19.5000 ± 0.216 11.5750 ± 0.275 14.2750 ± 0.13 3.7250 ± 0.132
Breviscapine 22.5000 ± 0.216*** 14.0000 ± 0.163*** 20.7750 ± 0.15*** 6.1633 ± 0.035***
Vitamin K1 16.5500 ± 0.129***### 10.9333 ± 0.115***### 13.5000 ± 0.26***### 4.6000 ± 0.145***###
Ar.TE 19.3750 ± 0.320###&&& 10.5000 ± 0.258***###& 14.5250 ± 0.19##&&& 6.7150 ± 0.153***###&&&
Ar.Pe 16.0500 ± 0.238***###&& 10.2500 ± 0.191***###&&& 18.6475 ± 0.20***###&&& 3.8350 ± 0.066###&&&
Ar.Ea 16.625 ± 0.222***### 11.0500 ± 0.238**### 17.2450 ± 0.19***###&&& 3.7175 ± 0.111###&&&
Ar.Bu 16.0967 ± 0.295***###& 10.8750 ± 0.275***### 15.2750 ± 0.25***&&& 3.9100 ± 0.071**###&&&
Acacetin 20.7225 ± 0.121***###&&& 12.5500 ± 0.311***###&&& 20.2750 ± 0.26***##&&& 2.8125 ± 0.142***###&&&
Tilianin 20.7500 ± 0.191***###&&& 12.2000 ± 0.082***###&&& 16.7475 ± 0.19***###&&& 3.1425 ± 0.111***###&&&
  1. Note: results were expressed as mean ± SD, n = 4. Compared with blank: *** P < 0.001; 0.001 < ** P < 0.01; Compared with breviscapine: ### P < 0.001; 0.001 < ## P < 0.01. Compared with Vitamin K1: &&&P < 0.001, 0.001 < &&P < 0.01, &P < 0.05