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Fig. 2 | BMC Complementary and Alternative Medicine

Fig. 2

From: Anti-inflammatory potential of Capparis spinosa L. in vivo in mice through inhibition of cell infiltration and cytokine gene expression

Fig. 2

The anti-inflammatory effect of CS is independent of the plant genotype and of the period of treatment. Different Groups of mice (≈5 mice per group) were sensitized on the shaved ventral abdomen on days 0 and 1 by applying 50 μl of 0.5% DNFB (positive control ■), or with the vehicle alone (negative control) and were all challenged with 20 μl of 0.2% DNFB on the right ears on day 6. Other groups were sensitized and challenged with DNFB and received i.p. injections of the first (CS. 1), second (CS.2) or third (CS.3) CS genotypes (a and b). In another series of experiments (c and d), mice received i.p. injections of CS extract on days -1, 0, 1 and 2 during the period of sensitization (s) or on days 5, 6 and 7, during the period of the challenge (c) at a dose of 1.07 g/Kg body weight or during the periods of sensitization and challenge (s + c). Data were represented as averages of ear swelling values after the challenge. P value <0.05 was considered to be significant [* p < 0.05; ** p < 0.01; *** p < 0.001]. e Genetic comparison of the three varieties of CS presenting with morphological differences. (a): quantitative descriptors, (b): qualitative descriptors and c: Qualitative versus quantitative descriptors and Photographs of leaves and flowers of these plant varieties. f Molecular profil of samples based on 4 distinct ISSR primers (Additional file 2)

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