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Table 4 Effect of N.alba AEE on CCl4-induced changes in the liver function parameters in rats. Rats were intoxicated with CCl4 (0.5 ml/kg; I.P.) and treated with N. alba (100 and 200 mg/kg; P.O.) and silymarin (100 mg/kg; P.O.) for 5 days. ALT, AST, total bilirubin, GGT and ALP were measured

From: Profile of bioactive compounds in Nymphaea alba L. leaves growing in Egypt: hepatoprotective, antioxidant and anti-inflammatory activity

Parameter

Control

CCl4

N.alba extract

Silymarin (100 mg/kg)

Low Dose (100 mg/kg)

High Dose (200 mg/kg)

ALT (U/L)1

32.6 ± 3.1

88.1 ± 7.3a

58.4 ± 4b

41.9 ± 2.6b

38.1 ± 2.2b

AST (U/L)2

68.5 ± 3.5

139 ± 8.3a

105.9 ± 4.1b

82.1 ± 6.1b

72.5 ± 4.7b

Total Bilirubin (mg/dl)

0.2 ± 0.02

1.2 ± 0.1a

0.5 ± 0.03b

0.3 ± 0.03b

0.2 ± 0.02b

GGT (U/L)3

7.7 ± 0.6

35.9 ± 3.3a

20.8 ± 1.8b

12.9 ± 1.2b

12 ± 1.2b

ALP (U/L)4

278.5 ± 19.1

496.5 ± 38.3a

414.7 ± 10.9b

346.6 ± 22.8b

294.2 ± 15.4b

  1. Data are presented as the mean ± SEM, n = 8. aSignificant difference from control group; P < 0.05. bSignificant difference from CCl4 group; P < 0.05
  2. 1Alanine aminotransferase
  3. 2Aspartate aminotransferase
  4. 3Gamma glutamyl transpeptidase
  5. 4Alkaline phosphatase