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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Sophorae Flos extract inhibits RANKL-induced osteoclast differentiation by suppressing the NF-κB/NFATc1 pathway in mouse bone marrow cells

Fig. 4

Effects of Sophorae Flos extract (SFE) on RANKL-induced intracellular signaling and expression of c-fos and NFATc1 in osteoclasts. Bone marrow macrophages were cultured with RANKL and MCSF in the presence or absence of SFE (100 μg/ml) for 4 days. Protein expression levels were evaluated by western blot analysis. a Activation of MAPKs and NF-κB measured using by their respective antibodies. Expression of (b) c-fos and (c) NFATc1 detected by the respective antibodies. All data are representative of at least three independent experiments

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