In vivo antimalarial activity of crude extracts and solvent fractions of leaves of Strychnos mitis in Plasmodium berghei infected mice

Table 5 Effect of fraction of S. mitis leaves on body weight of P. berghei infected mice

Test substances	Dose (mg/kg)	Body weight		% Change
Test substances	Dose (mg/kg)	D0 (g)	D4 (g)	% Change
NF	100	29.45 ± 1.46	30.48 ± 2.12	3.26 ± 2.68 a²
	200	29.40 ± 1.65	30.36 ± 2.47	2.94 ± 4.73 a²
	400	30.25 ± 1.63	30.86 ± 2.34	1.73 ± 5.74 a¹
CF	100	29.68 ± 1.55	29.28 ± 1.56	−1.40 ± 2.86
	200	29.75 ± 1.42	30.40 ± 2.37	1.89 ± 4.47 a²
	400	30.46 ± 1.70	31.11 ± 2.35	1.89 ± 4.02 a²
AF	100	29.43 ± 2.06	28.93 ± 2.02	−1.79 ± 4.07
	200	29.41 ± 1.79	29.75 ± 2.26	1.00 ± 2.75 a¹
	400	30.76 ± 0.91	31.35 ± 1.28	1.70 ± 5.20 a²
Vehicle	1 ml	30.51 ± 1.78	28.20 ± 1.59	−8.39 ± 7.04
CQ	25	29.23 ± 2.00	30.74 ± 2.53	4.79 ± 2.10 a³

Data are expressed as mean ± SEM; n = 6; a = compared to distilled water (vehicle), b = compared to100 mg/kg, c = compared to 200, d = compared to400 mg/kg, e = compared to chloroquine 25 mg/kg
D0 pre-treatment value on day 0, D4 post-treatment value on day four, CQ chloroquine, NF n-hexane fraction of crude hydro-methanolic extract, CF chloroform fraction of crude hydro-alcoholic extract, AF aqueous fraction of crude hydro-methanolic extract
¹ = p < 0.05, ² = p < 0.01, ³ = p < 0.001

ISSN: 2662-7671