In vivo antimalarial activity of crude extracts and solvent fractions of leaves of Strychnos mitis in Plasmodium berghei infected mice

Table 4 Effect of fractions of leaves of S. mitis on percent parasitaemia, percent suppression and survival time on P. berghei infected mice

Test substances	Dose (mg/kg)	% parasitaemia	% suppression	Survival time (day)
NF	100	28.68 ± 6.31	42.11 a³,e³	11.33 ± 1.21a³,e³
	200	28.31 ± 0.89	42.85 a³,e³	11.50 ± 1.76 a³.e³
	400	32.81 ± 4.38	33.77 a³,e³	11.00 ± 1.54 a³,e³
CF	100	36.25 ± 2.14	26.84 a³,d³.e³	10.50 ± 0.54 a³,e³
	200	33.83 ± 3.19	31.71a³,d¹,e³	10.83 ± 0.75 a³,e³
	400	29.86 ± 2.30	39.72 a³,b³,c¹,e³	11.33 ± 1.03 a³,e³
AF	100	37.26 ± 1.84	24.78 a³,d³,e³	10.16 ± 1.47 a²,e³
	200	36.10 ± 2.52	27.14a³,d²,e³	10.66 ± 1.36 a³,e³
	400	32.46 ± 2.18	34.47 a³,b³,c²,e³	11.16 ± 0.75 a³,e³
Vehicle	1 ml	49.55 ± 2.53	0.00	7.33 ± 1.03
CQ	25	0.00	100	27.83 ± 0.75

Data are expressed as mean ± SEM; n = 6; a = compared to distilled water (vehicle); b = compared to100 mg/kg; c = compared to 200; d = compared to400 mg/kg; e = compared to chloroquine 25 mg/kg
CQ chloroquine, NF n-hexane fraction of crude hydro-methanolic extract, CF chloroform fraction of crude hydro-methanolic extract, AF aqueous fraction of Crude hydro-methanolic extract
¹ = p < 0.05, ² = p < 0.01, ³ = p = <0.001

ISSN: 2662-7671