Fig. 5From: Bitter melon protects against ER stress in LS174T colonic epithelial cellsProposed mechanism of BME ameliorating ER stress. BME ameliorates ER stress by supressing the expression of CHOP, a downstream target of PERK-eIF2α-ATF4 pathway from triggering apoptosis in the cells. ATF4, Active transcription factor 4Back to article page