Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem

Table 6 Tail flick response of isolated compounds

Treatment/Dose	Time in Sec (Tail Flick)/Response (%)
Treatment/Dose	15 min	30 min	45 min	60 min	75 min	90 min
Control (2% Tween 80)	0.79 ± 0.017	0.87 ± 0.033	0.99 ± 0.024	0.94 ± 0.036	0.87 ± 0.029	0.90 ± 0.048
Ism-1 25 mg 50 mg	0.95 ± 1.12* (20.25%)	1.07 ± 0.112* (22.98%)	1.30 ± 0.131** (31.31%)	1.33 ± 0.124** (41.48%)	1.33 ± 0.163*** (52.87%)	1.33 ± 0.138*** (47.77%)
Ism-1 25 mg 50 mg	0.98 ± 1.20 (24.05%)	1.11 ± 0.411* (27.58%)	1.34 ± 0.161** (35.35%)	1.37 ± 0.201** (45.74%)	1.38 ± 0.206*** (58.62%)	1.36 ± 0.218*** (51.11%)
Standard (M)	1.20 ± 0.024 (48.14%)	2.03 ± 0.066 (56.15%)	3.89 ± 0.038 (75.06%)	6.30 ± 0.054 (85.07%)	4.40 ± 0.050 (80.22%)	4.30 ± 0.074 (78.37%)
N + 1 25 mg 50 mg	0.93 ± 0.045	0.94 ± 0.043	1.10 ± 0.052	0.99 ± 0.052	0.90 ± 0.058	0.93 ± 0.096
N + 1 25 mg 50 mg	0.89 ± 0.039	0.95 ± 0.068	1.50 ± 0.064	0.99 ± 0.047	0.89 ± 0.080	0.95 ± 0.089
M + N	0.80 ± 0.046	0.87 ± 0.037	0.94 ± 0.045	0.91 ± 0.033	0.91 ± 0.034	0.91 ± 0.045

All the values were expressed as mean ± SEM (n = 6). ^* P < 0.05, ^** P < 0.01 and ^*** P < 0.001 when compared to control group (one way ANOVA followed by Dunnetts: compared all vs control test)
Key: M Morphine 5 mg, N Naloxone 2 mg

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