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Table 2 The summery of 22 target genes involved in transactivation of NF-кB induced by IL-1β in NHDFs. All gene description and functional annotation were referred from PANTHER and NCBI databases

From: IL-1β-induced modulation of gene expression profile in human dermal fibroblasts: the effects of Thai herbal Sahatsatara formula, piperine and gallic acid possessing antioxidant properties

Group Gene symbol Description/Function
Transcription factor and their modulators CEBPD CCAAT/Enhancer Binding Protein (C/EBP), Delta /regulation of genes involved in immune and inflammatory responses (macrophage)
IRF1 Interferon Regulatory Factor 1/ an activator of interferons alpha and beta transcription, regulations of apoptosis and tumor-suppression
NFKB1 Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1/ sequence-specific DNA binding transcription factor activity and transcription factor binding
NFKBIA (IκBα) Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Alpha / inhibits the activity of dimeric NF-kappa-B/REL complexes
NFKBIZ (IκBZ) Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Zeta / a member of the ankyrin-repeat family, produce IL6 secretion induced by lipopolysaccharide.
TNFAIP3 Tumor Necrosis Factor, Alpha-Induced Protein3/ ubiquitin-protein transferase activity and inhibit NF-kappa B activation as well as TNF-mediated apoptosis
Chemokines and Interleukins CCL2 Chemokine (C-C Motif) Ligand 2/ A member of the CC subfamily contains chemotactic activity for monocytes and basophils
CXCL1 Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha)/ chemotactic activity for neutrophil
CXCL2 Chemokine (C-X-C Motif) Ligand 2/ produced by activated monocytes and neutrophils and expressed at sites of inflammation
CXCL6 Chemokine (C-X-C Motif) Ligand 6 /chemotactic activity for neutrophil
IL-6 Interleukin 6/ cytokine activity and interleukin-6 receptor, relation with B-cells, lymphocyte and monocyte differentiation,inflammation
IL-8 Chemokine (C-X-C Motif) Ligand 8/ the major mediators of the inflammatory response, chemotactic activity that attracts neutrophils, basophils and T-cell
Immunoreceptors CD83 CD83 Molecule/ an antigen presentation or the cellular interactions that follow lymphocyte activation
NOD2 Nucleotide-Binding Oligomerization Domain Containing 2/ protein kinase binding and peptidoglycan binding.
CFB Complement Factor B / serine-type endopeptidase activity and complement binding
Cell adhesion molecules and receptors ICAM1 Intercellular Adhesion Molecule 1/ a cell surface glycoprotein
NINJ1 Ninjurin 1/ Homophilic cell adhesion molecule
VCAM1 Vascular Cell Adhesion Molecule 1/ integrin binding and primary amine oxidase activity
Stress response genes SOD2 Superoxide Dismutase 2, Mitochondrial/ deSTFoys superoxide anions
Enzymes PTGES Prostaglandin E Synthase / catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2)
Early response genes TNFAIP2 Tumor Necrosis Factor, Alpha-Induced Protein 2/ a mediator of inflammation and angiogenesis
Miscellaneous TFPI2 Tissue Factor Pathway Inhibitor 2/ serine-type endopeptidase inhibitor activity and extracellular matrix STFuctural constituent