Group | Gene symbol | Description/Function |
---|---|---|
Transcription factor and their modulators | CEBPD | CCAAT/Enhancer Binding Protein (C/EBP), Delta /regulation of genes involved in immune and inflammatory responses (macrophage) |
IRF1 | Interferon Regulatory Factor 1/ an activator of interferons alpha and beta transcription, regulations of apoptosis and tumor-suppression | |
NFKB1 | Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1/ sequence-specific DNA binding transcription factor activity and transcription factor binding | |
NFKBIA (IκBα) | Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Alpha / inhibits the activity of dimeric NF-kappa-B/REL complexes | |
NFKBIZ (IκBZ) | Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Zeta / a member of the ankyrin-repeat family, produce IL6 secretion induced by lipopolysaccharide. | |
TNFAIP3 | Tumor Necrosis Factor, Alpha-Induced Protein3/ ubiquitin-protein transferase activity and inhibit NF-kappa B activation as well as TNF-mediated apoptosis | |
Chemokines and Interleukins | CCL2 | Chemokine (C-C Motif) Ligand 2/ A member of the CC subfamily contains chemotactic activity for monocytes and basophils |
CXCL1 | Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha)/ chemotactic activity for neutrophil | |
CXCL2 | Chemokine (C-X-C Motif) Ligand 2/ produced by activated monocytes and neutrophils and expressed at sites of inflammation | |
CXCL6 | Chemokine (C-X-C Motif) Ligand 6 /chemotactic activity for neutrophil | |
IL-6 | Interleukin 6/ cytokine activity and interleukin-6 receptor, relation with B-cells, lymphocyte and monocyte differentiation,inflammation | |
IL-8 | Chemokine (C-X-C Motif) Ligand 8/ the major mediators of the inflammatory response, chemotactic activity that attracts neutrophils, basophils and T-cell | |
Immunoreceptors | CD83 | CD83 Molecule/ an antigen presentation or the cellular interactions that follow lymphocyte activation |
NOD2 | Nucleotide-Binding Oligomerization Domain Containing 2/ protein kinase binding and peptidoglycan binding. | |
CFB | Complement Factor B / serine-type endopeptidase activity and complement binding | |
Cell adhesion molecules and receptors | ICAM1 | Intercellular Adhesion Molecule 1/ a cell surface glycoprotein |
NINJ1 | Ninjurin 1/ Homophilic cell adhesion molecule | |
VCAM1 | Vascular Cell Adhesion Molecule 1/ integrin binding and primary amine oxidase activity | |
Stress response genes | SOD2 | Superoxide Dismutase 2, Mitochondrial/ deSTFoys superoxide anions |
Enzymes | PTGES | Prostaglandin E Synthase / catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) |
Early response genes | TNFAIP2 | Tumor Necrosis Factor, Alpha-Induced Protein 2/ a mediator of inflammation and angiogenesis |
Miscellaneous | TFPI2 | Tissue Factor Pathway Inhibitor 2/ serine-type endopeptidase inhibitor activity and extracellular matrix STFuctural constituent |