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Table 2 The summery of 22 target genes involved in transactivation of NF-кB induced by IL-1β in NHDFs. All gene description and functional annotation were referred from PANTHER and NCBI databases

From: IL-1β-induced modulation of gene expression profile in human dermal fibroblasts: the effects of Thai herbal Sahatsatara formula, piperine and gallic acid possessing antioxidant properties

Group

Gene symbol

Description/Function

Transcription factor and their modulators

CEBPD

CCAAT/Enhancer Binding Protein (C/EBP), Delta /regulation of genes involved in immune and inflammatory responses (macrophage)

IRF1

Interferon Regulatory Factor 1/ an activator of interferons alpha and beta transcription, regulations of apoptosis and tumor-suppression

NFKB1

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1/ sequence-specific DNA binding transcription factor activity and transcription factor binding

NFKBIA (IκBα)

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Alpha / inhibits the activity of dimeric NF-kappa-B/REL complexes

NFKBIZ (IκBZ)

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Zeta / a member of the ankyrin-repeat family, produce IL6 secretion induced by lipopolysaccharide.

TNFAIP3

Tumor Necrosis Factor, Alpha-Induced Protein3/ ubiquitin-protein transferase activity and inhibit NF-kappa B activation as well as TNF-mediated apoptosis

Chemokines and Interleukins

CCL2

Chemokine (C-C Motif) Ligand 2/ A member of the CC subfamily contains chemotactic activity for monocytes and basophils

CXCL1

Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha)/ chemotactic activity for neutrophil

CXCL2

Chemokine (C-X-C Motif) Ligand 2/ produced by activated monocytes and neutrophils and expressed at sites of inflammation

CXCL6

Chemokine (C-X-C Motif) Ligand 6 /chemotactic activity for neutrophil

IL-6

Interleukin 6/ cytokine activity and interleukin-6 receptor, relation with B-cells, lymphocyte and monocyte differentiation,inflammation

IL-8

Chemokine (C-X-C Motif) Ligand 8/ the major mediators of the inflammatory response, chemotactic activity that attracts neutrophils, basophils and T-cell

Immunoreceptors

CD83

CD83 Molecule/ an antigen presentation or the cellular interactions that follow lymphocyte activation

NOD2

Nucleotide-Binding Oligomerization Domain Containing 2/ protein kinase binding and peptidoglycan binding.

CFB

Complement Factor B / serine-type endopeptidase activity and complement binding

Cell adhesion molecules and receptors

ICAM1

Intercellular Adhesion Molecule 1/ a cell surface glycoprotein

NINJ1

Ninjurin 1/ Homophilic cell adhesion molecule

VCAM1

Vascular Cell Adhesion Molecule 1/ integrin binding and primary amine oxidase activity

Stress response genes

SOD2

Superoxide Dismutase 2, Mitochondrial/ deSTFoys superoxide anions

Enzymes

PTGES

Prostaglandin E Synthase / catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2)

Early response genes

TNFAIP2

Tumor Necrosis Factor, Alpha-Induced Protein 2/ a mediator of inflammation and angiogenesis

Miscellaneous

TFPI2

Tissue Factor Pathway Inhibitor 2/ serine-type endopeptidase inhibitor activity and extracellular matrix STFuctural constituent