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Table 1 The cocktail probe of different concentration (μM)

From: Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes

Substrates Concentration Number
1 2 3 4 5 6 7
Caffeine(CAF) 1.875 3.75 7.5 15 30 60 120
Tolbutamide(D860) 0.625 1.25 2.5 5 10 20 40
(S)- Mephenytoin(MT) 1.25 2.5 5 10 20 40 60
Dextromethorphan(DM) 2.5 5 10 20 40 80 160
Chlorzoxazone(CLZ) 1.25 2.5 5 10 20 40 60
Midazolam(MDZ) 0.313 0.625 1.25 2.5 5 10 20