Fig. 5
From: Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes
Chromatograms of substrates, metabolites and the internal standard. (A-F): Substrates[A: Caffeine(CAF);B: Tolbutamide(D860);C: (S)-Mephenytoin(MT);D: Dextromethorphan(DM);E:Chlorzoxazone(CLZ);F: Midazolam(MDZ)]. (H-M) metabolites [H:Paraxanthine;I:4-Hydroxy Tolbutamide;J:(+/−)-4-Hydroxy Mephenytoin;K:Dextrorphan;L:6-Hydroxy chlorzoxazone;M:1-Hydroxymidazolam]. (G) The internal standard: Diazepam(DZP)