Table 1 Effect of administration of Melastoma malabathricum Linn. (MM) (28 days) on biochemical and hematological parameters in Wistar rats (Male and Female)
S. No | Parameters | Normal control | MM (500 mg/kg, b.w.) | MM (1000 mg/kg, b.w.) | MM (2000 mg/kg, b.w.) | ||||
|---|---|---|---|---|---|---|---|---|---|
Male | Female | Male | Female | Male | Female | Male | Female | ||
General effect | |||||||||
1 | Body Weight (gm) | 189.5 ± 8.34 | 156.2 ± 6.43 | 176.3 ± 6.34 | 145.3 ± 8.23 | 198.3 ± 9.76 | 151.2 ± 8.32 | 201.2 ± 11.34 | 161.3 ± 8.49 |
2 | Water Intake (mL) | 102 | 63 | 83 | 65 | 94 | 71 | 104 | 84 |
3 | Food Intake (gm) | 52 | 44 | 32 | 22 | 44 | 32 | 54 | 46 |
Hematology | |||||||||
1 | RBC (106/cu mm) | 6.43 ± 1.21 | 5.11 ± 1.02 | 5.98 ± 1.04 | 5.08 ± 0.95 | 6.87 ± 1.65 | 5.21 ± 1.43 | 7.65 ± 1.76 | 5.98 ± 1.09 |
2 | WBC (103/cu mm3) | 8.99 ± 1.43 | 7.21 ± 1.84 | 11.2 ± 1.65 | 9.43 ± 1.54 | 10.33 ± 1.64 | 8.65 ± 1.65 | 9.01 ± 1.59 | 7.43 ± 1.94 |
3 | Hb (g dL−1) | 13.01 ± 2.03 | 12.02 ± 2.21 | 12.54 ± 11.45 | 11.73 ± 1.98 | 13.06 ± 2.53 | 12.32 ± 2.04 | 14.03 ± 2.83 | 12.98 ± 2.47 |
4 | Platelet (105/cu mm) | 4.01 ± 0.73 | 3.83 ± 0.49 | 6 ± 2.01 | 5.87 ± 1.84 | 5.21 ± 1.03 | 5.01 ± 1.13 | 4.06 ± 0.94 | 3.78 ± 0.73 |
5 | Eosinophils (mm3) | 796 ± 293 | 498 ± 165 | 598 ± 384 | 398 ± 194 | 654 ± 403 | 432 ± 214 | 731 ± 421 | 489 ± 283 |
6 | Lymphocyte (mm3) | 3990 ± 850 | 2983 ± 594 | 4350 ± 1039 | 3214 ± 843 | 4256 ± 989 | 3103 ± 784 | 4013 ± 985 | 3023 ± 775 |
7 | Neutrophils (mm3) | 1596 ± 748 | 1374 ± 398 | 1698 ± 983 | 1485 ± 748 | 1602 ± 894 | 1398 ± 738 | 1545 ± 938 | 1367 ± 738 |
Biochemical | |||||||||
1 | ALP (UL−1) | 221 ± 21.83 | 209 ± 19.3 | 298 ± 31.78 | 285.2 ± 27.31 | 276.23 ± 24.54 | 244.5 ± 21.6 | 234 ± 24.5 | 213 ± 21.3 |
2 | ALT (UL−1) | 61.3 ± 2.34 | 50.32 ± 2.56 | ± | ± | ± | ± | ± | ± |
3 | AST (UL−1) | 103.2 ± 7.65 | 80.1 ± 7.87 | 90.3 ± 6.65 | 71.3 ± 8.76 | 95.6 ± 8.65 | 76.4 ± 7.54 | 102.3 ± 5.65 | 79.5 ± 6.87 |
4 | Bilirubin (mg dL−1) | 0.52 ± 0.09 | 0.36 ± 0.07 | 0.68 ± 0.08 | 0.43 ± 0.06 | 0.62 ± 0.06 | 0.41 ± 0.07 | 0.55 ± 0.08 | 0.40 ± 0.05 |
5 | Creatinine (mg dL−1) | 0.71 ± 0.43 | 0.52 ± 0.11 | 0.86 ± 0.22 | 0.64 ± 0.15 | 0.79 ± 0.14 | 0.58 ± 0.17 | 0.72 ± 0.21 | 0.54 ± 0.14 |
6 | Urea (mg dL−1) | 36 ± 3.21 | 26 ± 2.65 | 41.3 ± 4.54 | 35.1 ± 3.43 | 39.3 ± 3.54 | 32.1 ± 2.45 | 36.2 ± 4.32 | 28.5 ± 3.34 |
7 | Cholesterol (mg dL−1) | 71.3 ± 1.76 | 72.5 ± 1.54 | 82.6 ± 2.33 | 85.6 ± 3.46 | 79.6 ± 2.45 | 83.5 ± 3.43 | 75.3 ± 4.32 | 78.4 ± 3.45 |
8 | Triglyceride (mg dL−1) | 74.5 ± 1.87 | 86.7 ± 1.65 | 88.3 ± 1.76 | 89.6 ± 1.45 | 92.2 ± 2.43 | 93.3 ± 3.21 | 90.32 ± 2.32 | 92.3 ± 3.24 |
9 | HDL (mg dL−1) | 26.4 ± 1.41 | 20.6 ± 1.23 | 28.7 ± 2.73 | 22.4 ± 1.54 | 26.1 ± 1.83 | 21.3 ± 2.65 | 25.3 ± 2.43 | 20.3 ± 1.93 |
10 | LDL (mg dL−1) | 37.1 ± 1.23 | 49.83 ± 1.65 | 51.79 ± 2.13 | 60.73 ± 1.94 | 53.69 ± 1.86 | 61.91 ± 2.01 | 49.81 ± 1.28 | 58.01 ± 1.98 |
11 | VLDL (mg dL−1) | 14.9 ± 1.34 | 17.34 ± 1.67 | 17.66 ± 1.98 | 17.92 ± 1.56 | 18.44 ± 1.45 | 18.66 ± 1.76 | 18.06 ± 1.34 | 18.46 ± 1.54 |