Fig. 12

Histopathological effect of Melastoma malabathricum Linn. (MM) on CFA induced arthritic rats. a Normal Control: showed the normal architecture of articular cartilage; b AC control: showed the bone erosion, mononuclear cell infiltration and deformity of the bone with the presence of leukocytes infiltration (red arrow) and synovitis (blue arrow); c AC control + MM (100 mg/kg b.w.) showed the leukocytes infiltration (black arrow) and synovitis (yellow arrow); d AC control + MM (250 mg/kg b.w.) showed the leukocytes infiltration (black arrow); e AC control + MM (500 mg/kg b.w.) confirmed the normal architecture with less deformity of bone and cartilage; f AC control + Indo (10 mg/kg b.w.): treatment rats demonstrated the recovered histopathological profile towards normal architecture with less deformity of bone and cartilage