Skip to main content

Table 2 Cytotoxicity (LC50 in μg/mL) of compounds 1–3 and their selectivity index (SI)

From: Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut

Compounds Cytotoxicty (LC50) Selectivity Index*
HeLa cells Vero cells HeLa cells V. cholerae SG24 V. cholerae CO6 V. cholerae NB2 V. cholerae PC2 S. flexneri SDINT S. aureus ATCC 25923
1 8.18 ± 0.92a 93.02 ± 2.54a 11.37 / 0.18 0.18 / 0.72 0.72
2 35.69 ± 1.31b 129.10 ± 1.20b 3.61 / 0.25 0.25 0.50 1.00 0.50
3 3.66 ± 0.33c 73.88 ± 0.92c 20.18 / 0.14 0.14 / 0.57 0.14
5-FU 0.25 ± 0.05d 4.63 ± 0.17d 18.52 / / / / / /
  1. /: not determined; 5-FU 5-Fluorouridine; SI LC50 on Vero cells /MIC or LC50 on HeLa cells; *: SI obtained from average MIC. In the same column, LC50 value marked with different superscript letters (a, b, c, d) are significantly different (p < 0.05)
\