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Table 4 Anticancer activity of C. angustifolia extracts against HCEC, Hep2, HeLa, and Mcf-7cell lines

From: Pharmacologically active flavonoids from the anticancer, antioxidant and antimicrobial extracts of Cassia angustifolia Vahl

Cell Lines Extracts % Cell death I.C50
100 μg/μL 150 μg/μL 200 μg/μL 250 μg/μL μg/μL
HCEC Methanol 2.3 ± 0.76 1.83 ± 0.76 3.43 ± 0.50* 13.7 ± 2.42* 21.09
Ethanol 1.2 ± 0.52 6.23 ± 1.02* 9.20 ± 0.81* 12.8 ± 1.01* 16.23
  Taxol 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0 0.0
  Tamoxifen 14.5 ± 0.5 19.3 ± 0.7 26 ± 0.5 26.8 ± 0.7 6.29
Hep2 Ethanol 6.06 ± 0.49** 11.83 ± 0.65** 21.0 ± 0.90* 28.26 ± 0.25* 7.28
Taxol 26.5 ± 0.5 31.76 ± 0.66 35.53 ± 0.25 45.16 ± 0.60 3.97
HeLa Methanol 16.7 ± 0.70** 22.56 ± 0.40** 27.73 ± 0.2** 32.46 ± 0.61** 5.45
Ethanol 5.46 ± 0.40** 15.53 ± 0.37** 18.43 ± 0.4** 22.9 ± .075** 8.18
Taxol 11.46 ± 0.40 19.7 ± 0.51 24.63 ± 0.50 30.56 ± 0.45 6.07
MCF-7 Methanol 23.33 ± 0.7** 26.23 ± 0.25** 42.4 ± 0.36** 43.6 ± 0.45** 4.0
Ethanol 6.8 ± 0.52* 11.5 ± 0.37** 16.1 ± 0.1** 23.56 ± 0.45** 8.79
Tamoxifen 12.46 ± 0.40 17.36 ± 0.55 24.63 ± 0.50 28.56 ± 0.45 6.4
  1. Taxol and Tamoxifen are standard anticancer drugs taken as positive controls. Values represents the mean ± standard deviation of three replicates (n = 3)
  2. (*), and (**), significant at level P ≤ 0.01 and 0.001, respectively
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