Pharmacologically active flavonoids from the anticancer, antioxidant and antimicrobial extracts of Cassia angustifolia Vahl

Table 4 Anticancer activity of C. angustifolia extracts against HCEC, Hep2, HeLa, and Mcf-7cell lines

Cell Lines	Extracts	% Cell death				I.C₅₀
Cell Lines	Extracts	100 μg/μL	150 μg/μL	200 μg/μL	250 μg/μL	μg/μL
HCEC	Methanol	2.3 ± 0.76	1.83 ± 0.76	3.43 ± 0.50*	13.7 ± 2.42*	21.09
HCEC	Ethanol	1.2 ± 0.52	6.23 ± 1.02*	9.20 ± 0.81*	12.8 ± 1.01*	16.23
	Taxol	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0
	Tamoxifen	14.5 ± 0.5	19.3 ± 0.7	26 ± 0.5	26.8 ± 0.7	6.29
Hep2	Ethanol	6.06 ± 0.49**	11.83 ± 0.65**	21.0 ± 0.90*	28.26 ± 0.25*	7.28
Hep2	Taxol	26.5 ± 0.5	31.76 ± 0.66	35.53 ± 0.25	45.16 ± 0.60	3.97
HeLa	Methanol	16.7 ± 0.70**	22.56 ± 0.40**	27.73 ± 0.2**	32.46 ± 0.61**	5.45
	Ethanol	5.46 ± 0.40**	15.53 ± 0.37**	18.43 ± 0.4**	22.9 ± .075**	8.18
	Taxol	11.46 ± 0.40	19.7 ± 0.51	24.63 ± 0.50	30.56 ± 0.45	6.07
MCF-7	Methanol	23.33 ± 0.7**	26.23 ± 0.25**	42.4 ± 0.36**	43.6 ± 0.45**	4.0
	Ethanol	6.8 ± 0.52*	11.5 ± 0.37**	16.1 ± 0.1**	23.56 ± 0.45**	8.79
	Tamoxifen	12.46 ± 0.40	17.36 ± 0.55	24.63 ± 0.50	28.56 ± 0.45	6.4

Taxol and Tamoxifen are standard anticancer drugs taken as positive controls. Values represents the mean ± standard deviation of three replicates (n = 3)
(*), and (**), significant at level P ≤ 0.01 and 0.001, respectively

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