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Table 3 Efficacy of CAM antibacterial compounds on survival of E.coli 0157:H7 (1x106 CFU/ml) @ 8 h in 31 °C

From: Natural product HTP screening for antibacterial (E.coli 0157:H7) and anti-inflammatory agents in (LPS from E. coli O111:B4) activated macrophages and microglial cells; focus on sepsis

Anti-bacterial effects of natural compounds on E. coli 0157:H7 survival

Compound

LC50

Units

Penicillin/Streptomycin

0.01

Units/μg.ml

Cholloidal Silver-Argentym 23®

0.02

μg/ml

(+) Gossypol

1.5

μg/ml

Grapeseed Extract/Vitis Vinifera

1.8

μg/ml

Green Tea Extract/Camellia Sinensis

2.0

μg/ml

(-)-Epigallocatechin gallate

3.7

μg/ml

Doxorubin hydrochloride

5.4

μg/ml

Gallic Acid

8.4

μg/ml

Caffeic Acid

10.1

μg/ml

Chinese Gallnut

10.4

μg/ml

Babul Chall Bark/Acacia arabica

13.4

μg/ml

Polyphenon 60

14.1

μg/ml

Uva Ursi/Arctostaphylos uva ursi

19.1

μg/ml

Arjun/Terminalia arjuna

23.8

μg/ml

Balm of Gilead Bud/Populus candicans

26.7

μg/ml

Bayberry Root/Morella cerifera

28.5

μg/ml

Blood Root/Sanguinaria canadensis/

33.5

μg/ml

(-)-Gallocatechin

35.8

μg/ml

2-D08

37.0

μg/ml

Glyoxal Acid

39.6

μg/ml

Scutellarian

42.0

μg/ml

Kokum Black/Garcinia Indica

47.5

μg/ml

Indole

47.5

μg/ml

Trifala

47.7

μg/ml

CraneSbill Root/Geranium maculatum

51.6

μg/ml

Shi Liu Pi (Granati Peel)

60.4

μg/ml

Catuaba Bark/Trichilia Catigua

63.4

μg/ml

Chapparal/Larrea tridentata

73.6

μg/ml

Thymol

92.0

μg/ml

Esculetin

93.3

μg/ml

Epicatechin

114.0

μg/ml

Piperonal

115.1

μg/ml

(+)-Catechin

173.0

μg/ml

  1. The data represents LC50 values determined by regression analysis, on a minimum of 6 concentrations, (n = 4)