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Table 2 Efficacy of natural anti-inflammatory compounds relative to cellular toxicity in LPS activated BV-2 cells

From: Natural product HTP screening for antibacterial (E.coli 0157:H7) and anti-inflammatory agents in (LPS from E. coli O111:B4) activated macrophages and microglial cells; focus on sepsis

BV-2 microglia cells + 1μg/mL LPS: anti-inflammatory potency

Substance

Anti-inflammatory IC50 (μg/mL)

Toxicity LC50 (μg/mL)

iEI (LC50/IC50)

Cardamonin

1.6

265.0

>169.4

Dexamethasone

1.9

260.0

>136.8

Bay Leaf/Laurus nobilis

34.2

537.0

>15.7

Quercetin

27.8

250.0

>8.9

Apicidin

0.0

0.6

65.5

L-N-lysine dihydrochloride

4.2

247.2

58.8

Elecampane Root/Inula helenium

154.4

1486.0

35.7

Ashwagandha/Withania somnifera

166.4

2848.3

17.1

Hydrocortisone

13.0

219.2

16.9

Apigenin

25.2

337.0

13.4

Optilgold

9.4

113.6

12.1

Biochanin A

33.7

369.2

10.9

Tansy Herb/Tanacetum vulgare

143.0

1302.1

9.1

Feverfew/Tanacetum parthenium

28.2

230.2

8.2

Centipeda/Centipeda minima

258.4

2105.2

8.1

Osha Root/Ligusticum porteri

29.5

203.4

6.9

Eupatorin

39.3

265.2

6.7

Turmeric Root/Curcuma longa

74.4

498.9

6.7

Herb de province

167.2

1115.3

6.7

Granati peel/Punica granatum rind

75.7

439.1

5.8

Rabdosia rubescens Herb

34.5

192.7

5.6

Rosemary Lf/Rosmarinus officinali

43.0

214.8

5.0

Trifala

88.3

408.8

4.6

Green Tea Std Sigma T5550

38.0

169.7

4.5

Curcumin

10.2

43.2

4.2

Myrrh/Commiphora myrrha

31.8

132.8

4.2

Clove/Syzygium aromaticum

149.0

615.1

4.1

Indomethacin

17.9

67.2

3.7

Sage leaf/Salvia officinalis

80.3

298.4

3.7

Amla/Phyllanthus emblica

206.1

736.1

3.6

White Sage/Salvia apiana

79.2

282.0

3.6

Ganthoda

168.3

563.7

3.3

Succinum Resin

20.1

56.3

2.8

Genistein

5.6

14.7

2.6

Baicalein

7.8

20.1

2.6

Butein

1.2

2.9

2.3

Maddar root/Rubia tinctorum

59.2

135.0

2.3

Yerba Santa Lf/E. californicum

18.3

41.4

2.3

EGCG

11.3

24.8

2.2

Phloretin

17.2

37.8

2.2

Frankincense/Boswellia carterii

15.4

32.5

2.1

Fisetin

2.3

4.7

2.1

Piperine

36.2

75.1

2.1

Javentri Powder

16.5

34.1

2.1

Bergamottin

111.4

227.5

2.0

Cinnamon/Cinnamomum burmann

135.0

260.0

<1.92

  1. The data represent LC50 values for toxicity and IC50 values for NO2- reduction both determined by regression analysis on a minimum of 6 concentrations,(n = 4). The ratio of LC50/IC50 μg/mL is the iEI (in- vitro efficacy index), where the greater the value the greater the confidence in the anti-inflammatory effects. The symbol [>] denotes an iEI value acquired on a maximum upper limit concentration being tested