Table 1 Efficacy of anti-inflammatory CAMS relative to cellular toxicity in LPS activated RAW 264.7 cells
RAW 264.7 cells + 1μ/mL LPS: anti-inflammatory potency | |||
|---|---|---|---|
Substance | Anti-inflammatory IC50 (μg/mL) | Toxicity LC50 (μg/mL) | iEI (LC50/IC50) |
L-N-lysine dihydrochloride | 4.4 | 250.0 | >57.4 |
Cardamonin | 6.1 | 250.0 | >40.8 |
Dexamethasone | 1.6 | 260.0 | >22.4 |
Hydrocortisone | 45.6 | 250.0 | >5.4 |
Bay Leaf/Laurus nobilis | 92.6 | 537.0 | >5.8 |
Tansy Herb/Tanacetum vulgare | 76.7 | 934.9 | 12.2 |
Apicidin | 0.2 | 2.4 | 11.7 |
Apigenin | 30.8 | 252.0 | 8.2 |
Yerba Santa Lf/E. californicum | 194.0 | 1413.4 | 7.3 |
Butein | 8.0 | 57.9 | 7.3 |
Ashwagandha/Withania somnifera | 457.2 | 3306.0 | 7.2 |
Centipeda Herb/Centipeda minima | 213.7 | 1260.5 | 5.9 |
Rosemary Lf/Rosmarinus officinalis | 132.4 | 754.8 | 5.7 |
Feverfew/Tanacetum parthenium | 48.4 | 264.2 | 5.5 |
Green Tea Std sigma T5550 | 45.5 | 228.7 | 5.0 |
Elecampane Root/Inula helenium | 257.8 | 1276.0 | 4.9 |
Quercetin | 14.3 | 63.8 | 4.5 |
Commiphora myrrha resin | 127.1 | 5221.1 | 4.1 |
Amla/Phyllanthus emblica | 156.7 | 641.0 | 4.1 |
Herb de province | 203.4 | 793.2 | 3.9 |
Turmeric Root/Curcuma longa | 87.3 | 274.3 | 3.1 |
Biochanin A | 119.0 | 345.1 | 2.9 |
Trifala | 195.3 | 559.5 | 2.9 |
Cinnamon/Cinnamomum burmannii | 344.9 | 923.0 | >2.6 |
EGCG | 20.0 | 50.8 | 2.5 |
Bergamottin | 67.1 | 161.7 | 2.4 |
Osha Root/Ligusticum porteri | 43.4 | 104.1 | 2.4 |
Kalijiri Purple Fleablame | 58.0 | 130.0 | 2.2 |
Curcumin | 12.6 | 28.1 | 2.2 |
Rabdosia rubescens Herb | 104.9 | 220.3 | 2.1 |
White Sage/Salvia apiana | 62.0 | 129.5 | 2.1 |
Blood Root/Sanguinaria canadensis | 23.4 | 47.4 | 2.0 |