The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

Table 7 The effect of treating CCl₄ induced hepatotoxicity in male rats with olive oil and N. sativa oil for 4 weeks renal functions

Parameters mg/dl	Statistics	G1	G2	G3	G4
Parameters mg/dl	Statistics	N. Control	P. Control	Olive oil	Nigella sativa oil
Urea	Mean ± SE	24.00 ± 0.57 ^d	55.50 ± 1.25 ^a	43.83 ± 1.13^b	32.66 ± 1.33 ^c
	LSD 0.05 = 3.250	24.00 ± 0.57 ^d	55.50 ± 1.25 ^a	43.83 ± 1.13^b	32.66 ± 1.33 ^c
	T-test	-	−21.65^***	8.43^***	16.30^***
Creatinine	Mean ± SE	0.53 ± 0.02 ^d	1.70 ± 0.05 ^a	1.15 ± 0.04 ^b	0.79 ± 0.01 ^c
	LSD 0.05 = 0.117	0.53 ± 0.02 ^d	1.70 ± 0.05 ^a	1.15 ± 0.04 ^b	0.79 ± 0.01 ^c
	T-test	-	−16.34^***	11.00^***	15.72^***
Uric acid	Mean ± SE	4.18 ± 0.07 ^d	6.61 ± 0.09 ^a	6.01 ± 0.08 ^b	5.10 ± 0.07 ^c
	LSD 0.05 = 0.278	4.18 ± 0.07 ^d	6.61 ± 0.09 ^a	6.01 ± 0.08 ^b	5.10 ± 0.07 ^c
	T-test	-	−15.56^***	8.21^***	10.48^***

Data are represented as mean ± SE. T-test values ***: significant at P < 0.001. ANOVA analysis: within each row, means with different superscript (a, b, c or d) are significantly different at P < 0.05, whereas means superscripts with the same letters mean that there is no significant difference at P > 0.05. LSD least significant difference

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