Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats

Table 2 Identities and abundances of the 12 marker compounds corresponding to peaks 1–12 in the chromatogram of PSR shown in Fig. 1

Peak	Marker^a	Retention time (min)	Abundance (%)	Herbs indicated by the marker
1	Paeoniflorin	20.20	15.95 ± 0.94	P. lactiflora
2	Ferulic acid	28.57	0.51 ± 0.04	A. sinensis
				L. chuanxiong
3	Liquiritin	31.20	0.43 ± 0.05	G. uralensis
4	Ononin	45.78	0.16 ± 0.01	A. membranaceus
5	Lithospermic acid	48.19	0.64 ± 0.02	S. miltiorrhiza
6	Salvianolic acid B	52.67	1.62 ± 0.04	S. miltiorrhiza
7	Glycyrrhizic acid	68.14	1.41 ± 0.04	G. uralensis
8	Formononetin	68.45	0.53 ± 0.01	A. membranaceus
9	Ligustilide	75.76	0.25 ± 0.00	A. sinensis
				L. chuanxiong
10	Cryptotanshinone	78.78	0.25 ± 0.02	S. miltiorrhiza
11	Tanshinone I	79.39	3.81 ± 0.21	S. miltiorrhiza
12	Chrysophanol	80.18	0.52 ± 0.01	C. obtusifolia

^aAll the marker compounds of PSR except ononin have been demonstrated to be neuroprotective in rodent models of cerebral ischemia, and ononin can protect neuronal cells against glutamate-induced cytotoxicity [32, 34, 50–58]

ISSN: 2662-7671