Fig. 4

PSR pre-treatment reduces neurological deficit and cerebral infarct in MCAO rats. a Rats were pre-treated with vehicle (con) or different doses of PSR, and neurological scores were determined 24, 48, and 72 h after MCAO. Infarct area (b), infarct volume (c), and edema content (d) were measured 72 h after MCAO. For (a-c), the numbers of animals in the control, PSR 1.1, 2.2 and 5.5 g/kg groups were 17, 7, 10 and 10, respectively. For (D), n for control = 14. In (a, b), statistical significance between PSR-treated and control groups was analyzed by two-way ANOVA followed by Bonferroni post-test. For infarct area, the P-values of the differences between treatment groups and the corresponding controls of the same coronal slices are shown. In (c, d), statistical significance between PSR-treated and control groups was analyzed by one-way ANOVA followed by Newman-Keuls post-test. The key pattern shown in (a) applies to all other panels in this figure as well as in Fig. 5