Sex differences in acupuncture effectiveness in animal models of Parkinson's disease: a systematic review

Lee, Sook-Hyun; van den Noort, Maurits; Bosch, Peggy; Lim, Sabina

doi:10.1186/s12906-016-1405-5

BMC Complementary Medicine and Therapies

Table 1 Summary of acupuncture for animal PD models

From: Sex differences in acupuncture effectiveness in animal models of Parkinson's disease: a systematic review

First author (year)	Type of animal PD models	Sex of animal PD models	Drugs used to induce PD	Types of acupuncture	Types of acupuncture points	Evaluation of the treatment effectiveness
Bai (2014a) [22]	Undefined	Undefined	6-OHDA	EA	GV20, EX-HN5	DA
Bai (2014b) [8]	Undefined	Male	6-OHDA	EA	GV20, EX-HN5	Caspase-3
Feng (2014) [10]	C57BL/6	Male	MPTP	MA	Undefined	Pole-climbing test, BDNF, TH, DA
Yeo (2013) [19]	C57BL/6	Male	MPTP	MA	GB34, LR3	TH, gene expression
Alvarez-Fischer (2013) [7]	C57BL/6	Male	MPTP	BV	Undefined	DA, DOPAC, IL-1β, IL-6, TNF-α, HVA, TH, rotational test
Ding (2013) [11]	SD	Male	6-OHDA	EA	LI4, LR3	nNOS, GFAP
Wang (2013a) [9]	SD	Male	Rotenone	EA	GV16, LR3	TH, COX-2
Wang (2013b) [23]	SD	Male	Rotenone	EA	GV16, LR3	TH, p-p38 MARK, COX-2
Wang (2013c) [12]	SD	Male	Rotenone	EA	GV16, LR3	TH, SOD, GSH, CAT, MDA
Wang (2013d) [24]	SD	Male	Rotenone	EA	GV16, LR3	UCH-L1, UBE1, Parkin, TH, α-synuclein
Ding (2012) [25]	SD	Male	6-OHDA	EA	LI4, LR3	TH, GFAP, PCNA
Huang (2012) [26]	ICR	Male	MPTP	EA	GB34	Lamp 1, α-synuclein
Lu (2012) [27]	C57BL/6	Male	MPTP	EA	GV20, GV16, GB34	Locomotor counts, swimming test, pole-climbing test
Guo (2012) [28]	SD	Male	6-OHDA	EA	GV20, GV16, GB34	GSH, SOD, MDA, GSH-Px
Yang (2011) [29]	C57BL/6	Male	MPTP	EA	PC7	Pole-climbing test, TH, DA, DOPAC, HVA
Choi (2011) [18]	C57/BL6	Male	MPTP	MA	GB34, LR3	TH, DAT, gene expression
Kim (2011) [30]	C57BL/6	Male	MPTP	BV	ST36	MAC-1, iNOS, TH
Du (2011) [31]	SD	Male	6-OHDA	EA	GV20, GV14	GABA, rotational test
Wang (2011) [32]	C57BL/6	Male	MPTP	EA	ST36, SP6	TH, DA, DOPAC, HVA, SOD, GSH, GSH-Px
Doo (2010) [33]	C57BL/6	Male	MPTP	BV	GB34	TH
Hong (2010) [34]	C57BL/6	Male	MPTP	MA	GB34	Gene expression
Jun (2010) [35]	C57BL/6	Male	MPTP	BV	BL23	TH, caspase-3, iNOS
Kim (2010) [36]	C57BL/6	Male	MPTP	EA	GB34, GB39	DA
Park (2010) [37]	C57BL/6	Male	MPTP	BV	GB39, LI11, BL23	TH, MAC-1, HSP70
Sun (2010) [38]	C57BL/6	Male	MPTP	MA	GV20, GV14	Pole-climbing test, TH, DA, DOPAC
Wang (2010a) [39]	Wistar	Undefined	6-OHDA	EA	GV16, LR3	TH, DA
Wang (2010b) [40]	Wistar	Undefined	6-OHDA	EA	GV16, LR3,CV4, ST36	GDNF
Wang (2010c) [41]	C57/BL6	Male	MPTP	MA	GV20, GV14	Pole-climbing test, TH, DA, NA, DOPAC, 5HIAA, 5HT
Yu (2010) [42]	Wistar	Male	6-OHDA	MA	GB34, LR3, ST36, SP10	Rotational test, SOD, GSH-Px, CAT, GSH, MDA
Huang (2010) [43]	Wistar	Male	6-OHDA	EA	LI4, LR3	Rotational test, BDNF, TrKB
Choi (2009) [21]	C57/BL6	Male	MPTP	MA	LR3, GB34	TH, DAT
Kim (2009) [44]	C57BL/6	Male	MPTP	BV	BL23	TH, MAC-1, HSP70
Wang (2009a) [45]	Wistar	Male, Female	6-OHDA	EA	GV20, EX-NH5	TH, BDNF
Wang (2009b) [46]	Wistar	Male, Female	6-OHDA	EA	GV20, EX-NH5	TH, DAT
Kim (2008) [47]	C57BL/6	Male	MPTP	MA	GB34	TH
Guan (2008) [48]	C57BL/6	Male	MPTP	EA	GV20	Fn
Wang (2008) [49]	Wistar	Male, Female	6-OHDA	EA	GV20, EX-NH5	TH
Jeon (2008) [50]	C57BL/6	Male	MPTP	EA	GB34, SI3, BL62, ST36	Pole-climbing test, TH, DA, BDNF
Xie (2007) [51]	Wistar	Undefined	6-OHDA	MA	GV20	Rotational test, MDA, NO, SOD
Kang (2007) [52]	C57BL/6	Male	MPTP	MA	GB34, LR3	TH, COX-2, iNOS, DA, DOPAC, HVA
Huang (2007) [53]	SD	Male	6-OHDA	MA	GB34, LR3	TH
Luo (2007) [54]	Wistar	Male, Female	6-OHDA	EA	GV20, EX-NH5	NOS
Wang (2007) [55]	SD	Male, Female	6-OHDA	MA	GV20, GV16, GB34	Rotational test, DA
Jin (2006a) [56]	Wistar	Male, Female	6-OHDA	EA	Undefined	GSH, GSH-Px,SOD, MDA, NOS
Jin (2006b) [57]	Wistar	Male, Female	6-OHDA	EA	Undefined	DA, HVA, DOPAC
Ma (2006) [58]	Wistar	Male, Female	6-OHDA	EA	GV16, LR3	Rotational test, DA
Tang (2006) [59]	C57BL/6	Male	MPTP	EA	LI4, LR3	BDNF
Wang (2006) [60]	SD	Male, Female	6-OHDA	EA	GV16, LR6	Glutamic acid
Kim (2006) [61]	C57BL/6	Male	MPTP	MA	LR8, LR4, LR2	TH
Kim (2005) [62]	SD	Undefined	6-OHDA	MA	ST36	Rotational test, TH
Ma (2005) [63]	Wistar	Male, Female	6-OHDA	EA	GV16, LR3	Rotational test, SOD, GSH, GSH-Px
Wang (2005) [64]	Wistar	Undefined	6-OHDA	MA	GV16, LR3, CV4, ST36	TH
Park (2003) [65]	SD	Male	6-OHDA	MA	GB34, LR3, LI4, LI11	Rotational test, TH, TrkB
Liang (2002) [66]	Wistar	Female	MFB transection	EA	GV14, GV21	TH, BDNF
Lin (2000) [67]	SD	Male, Female	6-OHDA	EA	LR3, SP6, ST36, GB34	DA, HVA, DOPAC
He (1998) [68]	SD	Male, Female	6-OHDA	EA	GV20, GV14	DA, NA, 5HT
Zhu (1996) [69]	C57BL/6	Male	MPTP	MA	GV20	DA, DOPAC

Abbreviations: BDNF Brain-derived neurotrophic factor, BV Bee-venom acupuncture, CAT Catalase, Caspase-3: caspase protein, COX-2 Cyclooxygenase-2, DA Dopamine, DAT Dopamine active transporter, DOPAC Dihydroxyphenyl acetic acid, EA Electro-acupuncture, Fn Ferritin, GABA gamma-aminobutyric acid, GDNF Glial cell-derived neurotrophic factor, GFAP Glial fibrillary acidic protein, GSH Glutathione, GSHpx Glutathione peroxidase, HSP70 70 kilo Dalton heat shock proteins, HVA Homovanillic acid, IL-1β Interleukin-1 beta, IL-6 Interleukin-6, iNOS Inducible nitric oxide synthase, Lamp 1 Lysosomal-associated membrane protein 1, MA Manual acupuncture, MAC-1 Macrophage-1 antigen, MDA Malondialdehyde, NO Nitric oxide, nNos Neuronal nitric oxide synthase, MFB Medial forebrain bundle, MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, p-p38 MARK Phospho-p38 MAPK, PCNA Proliferating cell nuclear antigen, SD Sprague–Dawley, SOD Superoxide dismutase, TH Tyrosine hydroxylase, TNF-α Tumor necrosis factor alpha, TrkB Tropomyosin receptor kinase B, UBE1 Ubiquitin-like Modifier Activating Enzyme 1, UCH-L1 Ubiquitin C-terminal hydrolase, 5HIAA 5-Hydroxyindoleacetic acid, 5HT 5-hydroxytryptamine, 6-OHDA 6-hydroxydopamine

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ISSN: 2662-7671

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