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Table 1 Summary of acupuncture for animal PD models

From: Sex differences in acupuncture effectiveness in animal models of Parkinson's disease: a systematic review

First author (year) Type of animal PD models Sex of animal PD models Drugs used to induce PD Types of acupuncture Types of acupuncture points Evaluation of the treatment effectiveness
Bai (2014a) [22] Undefined Undefined 6-OHDA EA GV20, EX-HN5 DA
Bai (2014b) [8] Undefined Male 6-OHDA EA GV20, EX-HN5 Caspase-3
Feng (2014) [10] C57BL/6 Male MPTP MA Undefined Pole-climbing test, BDNF, TH, DA
Yeo (2013) [19] C57BL/6 Male MPTP MA GB34, LR3 TH, gene expression
Alvarez-Fischer (2013) [7] C57BL/6 Male MPTP BV Undefined DA, DOPAC, IL-1β, IL-6, TNF-α, HVA, TH, rotational test
Ding (2013) [11] SD Male 6-OHDA EA LI4, LR3 nNOS, GFAP
Wang (2013a) [9] SD Male Rotenone EA GV16, LR3 TH, COX-2
Wang (2013b) [23] SD Male Rotenone EA GV16, LR3 TH, p-p38 MARK, COX-2
Wang (2013c) [12] SD Male Rotenone EA GV16, LR3 TH, SOD, GSH, CAT, MDA
Wang (2013d) [24] SD Male Rotenone EA GV16, LR3 UCH-L1, UBE1, Parkin, TH, α-synuclein
Ding (2012) [25] SD Male 6-OHDA EA LI4, LR3 TH, GFAP, PCNA
Huang (2012) [26] ICR Male MPTP EA GB34 Lamp 1, α-synuclein
Lu (2012) [27] C57BL/6 Male MPTP EA GV20, GV16, GB34 Locomotor counts, swimming test, pole-climbing test
Guo (2012) [28] SD Male 6-OHDA EA GV20, GV16, GB34 GSH, SOD, MDA, GSH-Px
Yang (2011) [29] C57BL/6 Male MPTP EA PC7 Pole-climbing test, TH, DA, DOPAC, HVA
Choi (2011) [18] C57/BL6 Male MPTP MA GB34, LR3 TH, DAT, gene expression
Kim (2011) [30] C57BL/6 Male MPTP BV ST36 MAC-1, iNOS, TH
Du (2011) [31] SD Male 6-OHDA EA GV20, GV14 GABA, rotational test
Wang (2011) [32] C57BL/6 Male MPTP EA ST36, SP6 TH, DA, DOPAC, HVA, SOD, GSH, GSH-Px
Doo (2010) [33] C57BL/6 Male MPTP BV GB34 TH
Hong (2010) [34] C57BL/6 Male MPTP MA GB34 Gene expression
Jun (2010) [35] C57BL/6 Male MPTP BV BL23 TH, caspase-3, iNOS
Kim (2010) [36] C57BL/6 Male MPTP EA GB34, GB39 DA
Park (2010) [37] C57BL/6 Male MPTP BV GB39, LI11, BL23 TH, MAC-1, HSP70
Sun (2010) [38] C57BL/6 Male MPTP MA GV20, GV14 Pole-climbing test, TH, DA, DOPAC
Wang (2010a) [39] Wistar Undefined 6-OHDA EA GV16, LR3 TH, DA
Wang (2010b) [40] Wistar Undefined 6-OHDA EA GV16, LR3,CV4, ST36 GDNF
Wang (2010c) [41] C57/BL6 Male MPTP MA GV20, GV14 Pole-climbing test, TH, DA, NA, DOPAC, 5HIAA, 5HT
Yu (2010) [42] Wistar Male 6-OHDA MA GB34, LR3, ST36, SP10 Rotational test, SOD, GSH-Px, CAT, GSH, MDA
Huang (2010) [43] Wistar Male 6-OHDA EA LI4, LR3 Rotational test, BDNF, TrKB
Choi (2009) [21] C57/BL6 Male MPTP MA LR3, GB34 TH, DAT
Kim (2009) [44] C57BL/6 Male MPTP BV BL23 TH, MAC-1, HSP70
Wang (2009a) [45] Wistar Male, Female 6-OHDA EA GV20, EX-NH5 TH, BDNF
Wang (2009b) [46] Wistar Male, Female 6-OHDA EA GV20, EX-NH5 TH, DAT
Kim (2008) [47] C57BL/6 Male MPTP MA GB34 TH
Guan (2008) [48] C57BL/6 Male MPTP EA GV20 Fn
Wang (2008) [49] Wistar Male, Female 6-OHDA EA GV20, EX-NH5 TH
Jeon (2008) [50] C57BL/6 Male MPTP EA GB34, SI3, BL62, ST36 Pole-climbing test, TH, DA, BDNF
Xie (2007) [51] Wistar Undefined 6-OHDA MA GV20 Rotational test, MDA, NO, SOD
Kang (2007) [52] C57BL/6 Male MPTP MA GB34, LR3 TH, COX-2, iNOS, DA, DOPAC, HVA
Huang (2007) [53] SD Male 6-OHDA MA GB34, LR3 TH
Luo (2007) [54] Wistar Male, Female 6-OHDA EA GV20, EX-NH5 NOS
Wang (2007) [55] SD Male, Female 6-OHDA MA GV20, GV16, GB34 Rotational test, DA
Jin (2006a) [56] Wistar Male, Female 6-OHDA EA Undefined GSH, GSH-Px,SOD, MDA, NOS
Jin (2006b) [57] Wistar Male, Female 6-OHDA EA Undefined DA, HVA, DOPAC
Ma (2006) [58] Wistar Male, Female 6-OHDA EA GV16, LR3 Rotational test, DA
Tang (2006) [59] C57BL/6 Male MPTP EA LI4, LR3 BDNF
Wang (2006) [60] SD Male, Female 6-OHDA EA GV16, LR6 Glutamic acid
Kim (2006) [61] C57BL/6 Male MPTP MA LR8, LR4, LR2 TH
Kim (2005) [62] SD Undefined 6-OHDA MA ST36 Rotational test, TH
Ma (2005) [63] Wistar Male, Female 6-OHDA EA GV16, LR3 Rotational test, SOD, GSH, GSH-Px
Wang (2005) [64] Wistar Undefined 6-OHDA MA GV16, LR3, CV4, ST36 TH
Park (2003) [65] SD Male 6-OHDA MA GB34, LR3, LI4, LI11 Rotational test, TH, TrkB
Liang (2002) [66] Wistar Female MFB transection EA GV14, GV21 TH, BDNF
Lin (2000) [67] SD Male, Female 6-OHDA EA LR3, SP6, ST36, GB34 DA, HVA, DOPAC
He (1998) [68] SD Male, Female 6-OHDA EA GV20, GV14 DA, NA, 5HT
Zhu (1996) [69] C57BL/6 Male MPTP MA GV20 DA, DOPAC
  1. Abbreviations: BDNF Brain-derived neurotrophic factor, BV Bee-venom acupuncture, CAT Catalase, Caspase-3: caspase protein, COX-2 Cyclooxygenase-2, DA Dopamine, DAT Dopamine active transporter, DOPAC Dihydroxyphenyl acetic acid, EA Electro-acupuncture, Fn Ferritin, GABA gamma-aminobutyric acid, GDNF Glial cell-derived neurotrophic factor, GFAP Glial fibrillary acidic protein, GSH Glutathione, GSHpx Glutathione peroxidase, HSP70 70 kilo Dalton heat shock proteins, HVA Homovanillic acid, IL-1β Interleukin-1 beta, IL-6 Interleukin-6, iNOS Inducible nitric oxide synthase, Lamp 1 Lysosomal-associated membrane protein 1, MA Manual acupuncture, MAC-1 Macrophage-1 antigen, MDA Malondialdehyde, NO Nitric oxide, nNos Neuronal nitric oxide synthase, MFB Medial forebrain bundle, MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, p-p38 MARK Phospho-p38 MAPK, PCNA Proliferating cell nuclear antigen, SD Sprague–Dawley, SOD Superoxide dismutase, TH Tyrosine hydroxylase, TNF-α Tumor necrosis factor alpha, TrkB Tropomyosin receptor kinase B, UBE1 Ubiquitin-like Modifier Activating Enzyme 1, UCH-L1 Ubiquitin C-terminal hydrolase, 5HIAA 5-Hydroxyindoleacetic acid, 5HT 5-hydroxytryptamine, 6-OHDA 6-hydroxydopamine