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Table 1 EOs biological potential and selectivity indexes (SI) for L. amazonensis (IC50/24 h) promastigotes and L6 cells (CC50/24 h)

From: Essential oils: in vitro activity against Leishmania amazonensis, cytotoxicity and chemical composition

Essential oils

L. amazonensis

L6 cells

SIg

IC50a ± DP (μg/mL)

CC50 f ± DP (μg/mL)

Litsea cubeba

NIe

180.72 ± 1.37

-

Matricaria chamomilla

60.16 ± 4.24

173.04 ± 1.24

2.87

Elettaria cardamomum

>500.00b

439.57 ± 2.27

Lavandula officinalis

>500.00

377.56 ± 8.91

Cinnamomum camphora

>500.00

>500.00

Myroxylon peruiferum

162.25 ± 1.57

160.80 ± 1.62

0.99

Salvia sclarea

325.92 ± 8.58

375.37 ± 3.62

1.15

Bulnesia sarmientoi

85.56 ± 3.38

163.46 ± 1.77

1.91

Ferula galbaniflua

95.70 ± 1.82

377.26 ± 2.71

3.94

Pelargonium graveolens

363.71 ± 6.77

368.39 ± 3.90

1.01

Cananga odorata

NI

142.80 ± 1.76

Foeniculum officinalis

328. 28 ± 6.80

368.27 ± 3.81

1.12

Cordia verbenaceae

64.75 ± 2.04

130.00 ± 1.08

2.01

Melissa officinalis

132.02 ± 3.14

297.45 ± 1.32

2.25

Siparuna guianensis

48.55 ± 3.64

78.02 ± 1.19

1.60

Cinnamodendron dinisii

54.05 ± 4.88

106.31 ± 2.23

1.97

Anfotericina Bc

(0.083 ± 0.003 μg/mL)

NI

DMSOd

NI

NI

  1. a) IC50 ± DP: the concentration able to cripple 50 % of the parasites ± standard deviation
  2. b) > 500.00: IC50 greater than the highest concentration tested
  3. c) Amphotericin B - positive control
  4. d) DMSO - negative control
  5. e) NI: no inhibition
  6. f) CC50: the concentration able to cripple 50 % of cells after 24 h of treatment ± standard deviation
  7. g) Selectivity index - SI = CC50 L6 / IC50 promastigotes