Anti-inflammatory and antioxidative effects of six pentacyclic triterpenes isolated from the Mexican copal resin of Bursera copallifera

Table 1 Effect produced by resin and pure compounds 1–6 from B. copallifera on auricular edema induced by TPA in mice

	Edema inhibition (%) (1 mg/ear)	ID₅₀ μmol/ear
Total extract from B. copallifera resin	55.14 ± 3.85	0.707^a
3-epilupeol formiate (1)	62.16 ± 1.80	0.96
α-amyrin acetate (2)	69.45 ± 0.87	1.17
3-epilupeol acetate (3)	49.35 ± 3.6	>2.13
Lupenone (4)	57.25 ± 1.36	1.052
3-epilupeol (5)	66.39 ± 4.38	0.83
α-amyrin (6)	25.00 ± 1.81	>2.34
Indomethacin	91.35 ± 0.47	0.67

Data represent the mean ± S.D. of at least three independent experiments performed in triplicate. ^aThe dose was in mg/ear

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