Fig. 5

Effects of taxol and BGJTD treatments on Erk1/2 and Cdc2 activity in the sciatic nerve. Western blot analysis of phospho-Erk1/2 in the sciatic nerves (a) and in the DRG (b) after taxol injection and BGJTD treatments (T + B). c Western blot analysis of Cdc2 and phospho-vimentin in the sciatic nerves treated with DMSO vehicle, taxol, and taxol plus BGJTD. d Representative images showing Cdc2 and phospho-vimentin signals in S100β-labeled Schwann cells. Longitudinal sections from distal portion of the nerve treated with taxol and BGJTD were used in this experiment. Western blotting images in (a-c) are the representatives from 3 independent experiments. Quantitative comparison of mean band intensity for target proteins relative to actin control in western blotting are shown in lower panels in (a-c). Scale bars in (d): 100 μm