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Table 3 Detailed study procedures in the bioavailability study (30 mL single dose)

From: The NUTRAOLEOUM Study, a randomized controlled trial, for achieving nutritional added value for olive oils

Visit (V) number
IP, Intervention period
Enrolment V2
(IP 1)
V4
(IP 2)
V6
(IP 3)
Time Point, week Up to -12 2 7 12
Informed consent form X    
Randomization & allocation X    
Treatment distribution   X X X
Blood collection at baseline (0 h) and at 30 min, 45 min, 1 h, 2 h, 4 h, 6 h, 8 h, 10 h, 12 h, and 24 h after oils ingestion   X X X
Urine collection at baseline (0 h) and at
0–2 h, 2–4 h, 4–6 h, 6–8 h, 8–10 h, 10–12 h, 12–24 h, after oils ingestion
  X X X
Assessments
Primary outcomes
  Urinary tyrosol and hydroxytyrosol at 0–2 h, 2–4 h, 4–6 h, 6–8 h, 8–10 h, 10–12 h, 12–24 h, after oils ingestion   X X X
  Plasma Triterpenes at baseline (0 h) and at 30 min, 45 min, 1 h, 2 h, 4 h, 6 h, 8 h, 10 h, 12 h, and 24 h after oils ingestion   X X X
  Endothelial function measurements at baseline (0 h) and at 4 h, and 6 h, after oils ingestion   X X X
Secondary outcomes
  Plasma gastrointestinal hormones t baseline (0 h) and at 2 h, 4 h, and 6 h, after oils ingestion   X X X