Table 2 Detailed study procedures in the sustained consumption study (0 mL/day, 3-week intervention periods)

Time Point, week

(Week range)

Up to -12

0

(0–2)

2

(2–5)

5

(5–7)

7

(7–10)

10

(10–12)

12

(12–15)

15

Screening routine laboratory analyses

X

Demographic/ habits information-taking

X

Informed consent form

X

Randomization & allocation

X

Treatment distribution

X

X

X

Blood and 24 h-urine collection at fasting

X

X

X

X

X

X

X

  General medical questionnaire

X

X

X

X

X

X

X

  Alcohol consumption questionnaire

X

X

X

X

  3-day dietary record

X

X

X

X

  Minnesota Leisure Time Physical Activity questionnaire

X

X

  Blood pressure and anthropometric

X

X

X

X

X

X

X

  Visual Analogue Scale

X

X

X

  Monitoring adverse effects

X

X

X

  Compliance check (containers)

X

X

X

  Plasma Lipid profile

X

X

X

X

X

X

X

  Plasma Lipid and DNA oxidation

X

X

X

X

X

X

X

  Plasma Inflammation markers

X

X

X

X

X

X

X

  Plasma Antioxidant vitamins

X

X

X

X

X

X

X

  Plasma fatty acids

X

X

X

X

X

X

X

  Serum Endothelin

X

X

X

X

X

X

X

  Ex vivo cell immune response

X

X

X

X

  Urinary tyrosol and hydroxytyrosol

X

X

X

X

X

X

X

  Plasma Triterpenes

X

X

X

X

X

X

X