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Table 1 The associations between BBR concentrations and BA, related genes and gut microbiota in mice

From: Dose-response effect of berberine on bile acid profile and gut microbiota in mice

Name

Spearman R value

P value (<0.05)

Bile acids in the liver

 TLCA

−0.7140

0.000003

 TDCA

−0.6321

0.00008

 THDCA

−0.5581

0.0007

 DCA

−0.5574

0.0008

 LCA

−0.5341

0.001

 HDCA

−0.4834

0.004

 TMDCA

−0.4045

0.02

 MDCA

−0.3991

0.021

 TωMCA

−0.3918

0.024

 UDCA

0.4347

0.011

 TUDCA

0.5034

0.003

 TβMCA

0.5898

0.0003

 βMCA

0.6153

0.0001

Bile acids in the serum

 TDCA

−0.5305

0.001

 DCA

−0.5062

0.003

 βMCA

0.5112

0.002

Bile acids-related genes

 Oatp1b2

0.4137

0.017

 Bsep

0.4611

0.007

 Mdr2

0.5812

0.0004

 Cyp8b1

0.6047

0.0002

 Cyp7a1

0.6495

0.00004

 Ntcp

0.6510

0.00004

 FXR (in liver)

0.6944

0.000007

Bacteria in terminal ileum and large intestinal contents

 Lactobacillus murinus

−0.9165

0.00003

 Ruminococcus gnavus

−0.8870

0.0001

 Ruminococcus schinkii

−0.8574

0.0004

 Lactobacillus acidophilus

−0.8278

0.0009

 Eubacterium desmolans

−0.7687

0.003

 Lactococcus lactis

−0.6209

0.031

 Lactobacillus reuteri

−0.5617

0.057