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Fig. 5 | BMC Complementary and Alternative Medicine

Fig. 5

From: Dose-response effect of berberine on bile acid profile and gut microbiota in mice

Fig. 5

mRNA expression of major BA-related genes in livers of control and BBR-treated mice were examined (Fig. 5). BA synthetic enzymes involved in classical and alternative pathway were quantified in liver of BBR-treated mice (a). The mRNA expression of major BAs regulating factors in liver including FXR, SHP and Fgfr4 is demonstrated in (b). c illustrates the mRNA expression of major uptake transporters on the basolateral membrane of hepatocyte, which include Ntcp, Oatp1b2. The mRNA expression of major efflux transporters on the basolateral and canalicular membrane of hepatocyte are shown in (d). The left panel in d demonstrates the alteration of major efflux transporters on the canalicular membrane. The right panel of d shows the change of major efflux transporters on the basolateral membrane transporting the bile acids back to the blood after various doses of BBR. All values are expressed as mean ± S.E.M. ANOVA followed by Duncan’s post hoc test were used, and * means P < 0.05 when compared with controls

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