Skip to main content

Table 2 Effect of the fractions of Croton macrostachyus leaves on castor oil induced enteropooling in mice

From: Evaluation of the anti-diarrheal activity of the leaf extract of Croton macrostachyus Hocsht. ex Del. (Euphorbiaceae) in mice model

Dose administered

Volume of intestinal content (ml)

% of inhibition

Mean weight of intestinal content(gm)

% of inhibition

Control

0.67 ± 0.21

-------

0.78 ± 0.16

-------

Loperamide 3 mg/kg

0.12 ± 0.08a**

82.1

0.21 ± 0.08a**

73.08

CF300mg/kg

0.18 ± 0.054a*

73.13

0.27 ± 0.09a**

65.38

CF400mg/kg

0.17 ± 0.03a*

74.6

0.269 ± 0.06a**

65.51

CF500mg/kg

0.16 ± 0.04a**

76.12

0.248 ± 0.04a**

68.21

Control

0.77 ± 0.17

-------

0.83 ± 0.2

-------

Loperamide 3 mg/kg

0.12 ± 0.08a***

84.41

0.21 ± 0.078a**

74.70

MF300mg/kg

0.30 ± 0.05a*

61.04

0.36 ± 0.11a*

56.63

MF400mg/kg

0.20 ± 0.04a**

74.03

0.31 ± 0.04a*

62.65

MF500mg/kg

0.19 ± 0.02a**

75.32

0.29 ± 0.03a*

65.06

Control

0.47 ± 0.06

-------

0.45 ± 0.07

-------

Loperamide 3 mg/kg

0.083 ± 0.01a**c*d*e*f*

82.34

0.08 ± 0.01a*c*d*e*f*

82

AF300mg/kg

0.43 ± 0.098b*

8.5

0.44 ± 0.08b*

2.22

AF400mg/kg

0.38 ± 0.07b*

19.12

0.43 ± 0.12b*

4.44

AF500mg/kg

0.362 ± 0.09b*

22.98

0.422 ± 0.09b*

6.22

AF1000mg/kg

0.35 ± 0.06b*

25.53

0.41 ± 0.05b*

8.89

  1. Values are expressed as Mean ± S.E.M (n = 6), analysis was performed with One-Way ANOVA followed by Tukey test;a compared to control,b to standard drug,c to 300 mg/kg,d to 400 mg/kg,e to 500 mg/kg,f to 1000 mg/kg,g to CF300 mg/kg,h to CF 400 mg/kg andI to CF500 mg/kg; *P <0.05, **P <0.01, ***P <0.001; CF chloroform fraction, MF methanol fraction, AF aqueous fraction. Negative controls were treated with the vehicle used for reconstitution (2 % v/v Tween 80 for the chloroform and methanol fractions or distilled water for the aqueous fraction) orally