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Table 2 Effect of the fractions of Croton macrostachyus leaves on castor oil induced enteropooling in mice

From: Evaluation of the anti-diarrheal activity of the leaf extract of Croton macrostachyus Hocsht. ex Del. (Euphorbiaceae) in mice model

Dose administered Volume of intestinal content (ml) % of inhibition Mean weight of intestinal content(gm) % of inhibition
Control 0.67 ± 0.21 ------- 0.78 ± 0.16 -------
Loperamide 3 mg/kg 0.12 ± 0.08a** 82.1 0.21 ± 0.08a** 73.08
CF300mg/kg 0.18 ± 0.054a* 73.13 0.27 ± 0.09a** 65.38
CF400mg/kg 0.17 ± 0.03a* 74.6 0.269 ± 0.06a** 65.51
CF500mg/kg 0.16 ± 0.04a** 76.12 0.248 ± 0.04a** 68.21
Control 0.77 ± 0.17 ------- 0.83 ± 0.2 -------
Loperamide 3 mg/kg 0.12 ± 0.08a*** 84.41 0.21 ± 0.078a** 74.70
MF300mg/kg 0.30 ± 0.05a* 61.04 0.36 ± 0.11a* 56.63
MF400mg/kg 0.20 ± 0.04a** 74.03 0.31 ± 0.04a* 62.65
MF500mg/kg 0.19 ± 0.02a** 75.32 0.29 ± 0.03a* 65.06
Control 0.47 ± 0.06 ------- 0.45 ± 0.07 -------
Loperamide 3 mg/kg 0.083 ± 0.01a**c*d*e*f* 82.34 0.08 ± 0.01a*c*d*e*f* 82
AF300mg/kg 0.43 ± 0.098b* 8.5 0.44 ± 0.08b* 2.22
AF400mg/kg 0.38 ± 0.07b* 19.12 0.43 ± 0.12b* 4.44
AF500mg/kg 0.362 ± 0.09b* 22.98 0.422 ± 0.09b* 6.22
AF1000mg/kg 0.35 ± 0.06b* 25.53 0.41 ± 0.05b* 8.89
  1. Values are expressed as Mean ± S.E.M (n = 6), analysis was performed with One-Way ANOVA followed by Tukey test;a compared to control,b to standard drug,c to 300 mg/kg,d to 400 mg/kg,e to 500 mg/kg,f to 1000 mg/kg,g to CF300 mg/kg,h to CF 400 mg/kg andI to CF500 mg/kg; *P <0.05, **P <0.01, ***P <0.001; CF chloroform fraction, MF methanol fraction, AF aqueous fraction. Negative controls were treated with the vehicle used for reconstitution (2 % v/v Tween 80 for the chloroform and methanol fractions or distilled water for the aqueous fraction) orally