Fig. 5From: Comparison of cytotoxicity between extracts of Clinacanthus nutans (Burm. f.) Lindau leaves from different locations and the induction of apoptosis by the crude methanol leaf extract in D24 human melanoma cellsTransmission electron micrographs of the control (untreated) D24 cell (a) and cells treated with the crude MeOH extract (2Â mg/mL) for 72Â h (b & c). Distinct morphological changes, including plasma membrane alteration (white arrow), chromatin condensation (white arrowhead), blebbing (black arrow) and segmented/lobulated nucleus (black arrowhead) were observed in the treated cells. Cr: chromatin, MV: microvilli, NM: nuclear membrane, Nu: nucleus, PM: plasma membraneBack to article page