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Table 3 Effect of the aqueous and methanol leaf extracts of Verbascum sinaiticum on packed cell volume of Trypanosoma congolense infected mice

From: Antitrypanosomal activity of Verbascum sinaiticum Benth. (Scrophulariaceae) against Trypanosoma congolense isolates

Days

PCV Values

DA28

TW80

VSAE100

VSAE200

VSAE400

VSME100

VSME200

VSME400

Pre-infection

51.18 ± 0.37

50.88 ± 0.14

51.38 ± 0.18

51.18 ± 0.24

51.44 ± 0.12

51.22 ± 0.19

51.30 ± 0.27

51.48 ± 0.23

Day 0

49.40 ± 0.23

49.04 ± 0.29

49.10 ± 0.19

49.18 ± 0.18

49.24 ± 0.16

49.20 ± 0.22

49.24 ± 0.17

48.88 ± 0.20

Day 7

48.88 ± 0.25d**

44.78 ± 0.37

44.78 ± 0.36

46.08 ± 0.32a*,b*

48.24 ± 0.18abc**

44.76 ± 0.27

47.40 ± 0.41ab**

47.56 ± 0.16 ab**

%change PCV day 7–0

−1.05

−8.69

−8.79

−6.3

−2.03

−9.02

−3.73

−2.7

Day 14

50.08 ± 0.15d**

40.58 ± 0.27d**

43.72 ± 0.39a**

45.32 ± 0.37a**, b*

47.14 ± 0.25d**

44.30 ± 0.32 a**

46.80 ± 0.18 ab**

46.88 ± 0.35 ab**

% change PCV day 7–14

2.45

−9.38

−2.36

−1.65

−2.28

−1.02

−1.09

−1.59

  1. Values are expressed in Mean ± S.E.M; N = 5; DA28 diminazine aceturate 28 mg/kg- the positive control; VSAE V. sinaiticum aqueous extract; acompared to TW80 = 2 % tween 80-the negative control; bcompared to VSAE 100 mg/kg; ccompared to VSAE 200 mg/kg; dcompared with all groups; *p < 0.05 and **p < 0.001