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Table 2 The effect of aqueous and methanol leaf extracts of Verbascum sinaiticum on parasitaemia level of Trypanosoma congolense infected mice

From: Antitrypanosomal activity of Verbascum sinaiticum Benth. (Scrophulariaceae) against Trypanosoma congolense isolates

Days

Parasitaemia level (log number/ml)

DA28

TW80

VSAE100

VSAE200

VSAE400

VSME100

VSME200

VSME400

Day0

7.68 + 0.18

7.44 + 0.17

7.32 + 0.07

7.08 + 0.07

7.31 + 0.11

7.44 + 0.11

7.08 + 0.15

7.32 + 0.12

Day2

0.00 + 0.00d***

7.74 + 0.17

7.56 + 0.11

7.44 + 0.11

7.56 + 0.11

7.68 + 0.12

7.56 + 0.11

7.62 + 0.12

Day4

0.00 + 0.00d***

7.86 + 0.11

7.50 + 0.09

7.80 + 0.13

7.32 + 0.07a**,c*

7.50 + 0.16

7.32 + 0.07a*

7.26 + 0.11a**

Day6

0.00 + 0.00d***

8.16 + 0.11 d***

7.32 + 0.00a***

7.44 + 0.17a***

7.14 + 0.11a***

7.44 + 0.11a***

7.02 + 0.07a***,b*

6.96 + 0.11a***,b*

Day8

0.00 + 0.00d***

8.28 + 0.07d***

7.44 + 0.06a***

7.38 + 0.07a***

6.78 + 0.12d***

7.68 + 0.12a***

6.66 + 0.06ab***

6.54 + 0.11ab***

Day10

0.00 + 0.00d***

8.52 + 0.12 d***

7.74 + 0.11a***

7.62 + 0.07a***

7.08 + 0.12d***

7.86 + 0.11a***

7.14 + 0.11ab***

6.36 + 0.17abc***

Day12

2.16 + 1.32d***

8.64 + 0.06

8.04 + 0.11

7.92 + 0.12

7.56 + 0.11

7.98 + 0.07

7.44 + 0.11

6.72 + 0.20

Day14

5.52 + 0.07d***

8.82 + 0.12

8.40 + 0.09

8.16 + 0.11a***

8.04 + 0.11a***

8.28 + 0.07a*

7.74 + 0.11a***,b*

7.20 + 0.16ab***,c*

  1. Values are in Mean ± SEM; N = 5; DA28 diminazine aceturate 28 mg/kg-the positive control; VSAE V. sinaiticum aqueous extract; acompared to TW80 = 2 % tween 80-the negative control; bcompared to VSME 100 mg/kg; ccompared to VSAE 200 mg/kg; dcompared with all groups; *p < 0.05, **p < 0.01 and ***p < 0.001