Fig. 1

The experiment design of mice was induced Colitis Associated Colon Cancer (CAC) and DPE administration. Mouse was induced firstly by azoxymethane (AOM) and followed by administration of drinking water containing 5 % dextran sodium sulfate (DSS) in a cycle protocol for 7 days at weeks (1, 3, 5, 7, 9, 11, 13, 15, 17, 19 and 21) and followed by seven days of regular water at weeks (2, 4, 6, 8, 10, 12, 14, 16, 18 and 20). For the experiment, mice were divided into 5 groups; I received water (control); II was given DSS only; III-V groups were treated DPE (125 mg/kg BW, 250 mg/kg BW and 500 mg/kg BW), respectively. The administrated of DPE were started from the 8^th weeks until 21^th weeks. At the end of 21 weeks, mice in all groups were sacrificed ○ = PBS, ● = AO, ↓= DSS, ▲ = water (H₂O), ↕ = DPE