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Table 3 Hematological values of rats treated with MHEE for 4 weeks

From: Acute and subacute toxicity of an ethanolic extract of Melandrii Herba in Crl:CD sprague dawley rats and cytotoxicity of the extract in vitro

Dose (mg/kg/day)

0

500

1000

2000

Male rats

 WBC (103/μL)

9.2 ± 3.08

8.4 ± 2.14

9.5 ± 1.02

9.6 ± 1.66

 Reticulocytes (%)

2.8 ± 0.45

2.7 ± 0.31

2.4 ± 0.34

2.9 ± 0.64

 Neutrophils (%)

11.6 ± 2.19

9.4 ± 3.11

8.0 ± 2.75

13.6 ± 9.17

 Lymphocytes (%)

83.9 ± 2.51

86.1 ± 3.42

88.3 ± 2.64

80.2 ± 9.79

 Eosinophils (%)

1.0 ± 0.44

0.9 ± 0.23

0.7 ± 0.17

0.7 ± 0.26

 Monocytes (%)

1.8 ± 0.50

1.8 ± 0.42

1.7 ± 0.57

3.0 ± 0.48**

 Basophils (%)

0.7 ± 0.14

0.6 ± 0.09

0.4 ± 0.13**

0.5 ± 0.04*

 Large unstained cells (%)

1.1 ± 0.33

1.1 ± 0.27

0.9 ± 0.17

2.0 ± 0.75

 RBC (106/μL)

8.4 ± 0.24

8.2 ± 0.34

8.1 ± 0.25

8.0 ± 0.43

 Hematoglobin (g/dL)

16.4 ± 0.63

16.4 ± 0.78

16.6 ± 0.63

16.5 ± 0.58

 Hematocrit (%)

50.6 ± 1.32

50.4 ± 1.63

50.5 ± 0.98

50.2 ± 1.86

 MCV (fL)

60.4 ± 1.32

61.5 ± 1.46

62.2 ± 1.24

63.1 ± 2.54

 MCH (pg)

19.5 ± 0.50

20.1 ± 0.56

20.5 ± 0.61

20.7 ± 1.1

 MCHC (g/dL)

32.3 ± 1.27

32.6 ± 0.55

33.0 ± 0.65

32.9 ± 0.80

 Platelet (103/μL)

1038.0 ± 114.18

980.0 ± 61.93

1015.8 ± 111.26

1014.6 ± 74.29

Female rats

 WBC (103/μL)

5.9 ± 1.60

7.2 ± 1.06

8.6 ± 2.46

6.4 ± 1.06

 Reticulocytes (%)

2.6 ± 0.52

2.6 ± 0.58

2.9 ± 0.25

2.7 ± 0.67

 Neutrophils (%)

10.0 ± 1.90

14.8 ± 7.42

13.2 ± 6.83

7.8 ± 1.71

 Lymphocytes (%)

85.7 ± 2.25

81.1 ± 7.82

83.3 ± 6.74

87.9 ± 1.95

 Eosinophils (%)

1.0 ± 0.35

0.7 ± 0.17

0.9 ± 0.25

1.2 ± 0.64

 Monocytes (%)

1.9 ± 0.41

1.7 ± 0.54

1.4 ± 0.11

1.7 ± 0.50

 Basophils (%)

0.4 ± 0.19

0.4 ± 0.17

0.3 ± 0.16

0.4 ± 0.18

 Large unstained cells (%)

1.0 ± 0.11

1.2 ± 0.18

1.0 ± 0.25

1.0 ± 0.21

 RBC (106/μL)

8.18 ± 0.42

8.3 ± 0.45

7.8 ± 0.34

8.1 ± 0.42

 Hematoglobin (g/dL)

16.3 ± 0.87

16.1 ± 0.56

15.8 ± 0.43

16.0 ± 0.68

 Hematocrit (%)

48.7 ± 2.36

48.6 ± 2.36

47.7 ± 1.84

47.6 ± 2.15

 MCV (fL)

59.6 ± 0.80

58.8 ± 1.61

60.9 ± 0.92

59.2 ± 0.70

 MCH (pg)

19.9 ± 0.28

19.5 ± 0.74

20.2 ± 0.66

19.8 ± 0.34

 MCHC (g/dL)

33.4 ± 0.59

33.2 ± 0.99

33.1 ± 0.76

33.5 ± 0.41

 Platelet (103/μL)

1063.8 ± 47.47

1004.6 ± 104.58

1142.8 ± 121.17

1181.4 ± 182.15

  1. Values are presented as the mean ± SD
  2. *, ** indicate a significant difference at P < 0.05 and P < 0.01, respectively, when compared with the vehicle control group
  3. MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, PT prothrombin time