Dose (mg/kg/day) | 0 | 500 | 1000 | 2000 |
---|---|---|---|---|
Male rats | ||||
WBC (103/μL) | 9.2 ± 3.08 | 8.4 ± 2.14 | 9.5 ± 1.02 | 9.6 ± 1.66 |
Reticulocytes (%) | 2.8 ± 0.45 | 2.7 ± 0.31 | 2.4 ± 0.34 | 2.9 ± 0.64 |
Neutrophils (%) | 11.6 ± 2.19 | 9.4 ± 3.11 | 8.0 ± 2.75 | 13.6 ± 9.17 |
Lymphocytes (%) | 83.9 ± 2.51 | 86.1 ± 3.42 | 88.3 ± 2.64 | 80.2 ± 9.79 |
Eosinophils (%) | 1.0 ± 0.44 | 0.9 ± 0.23 | 0.7 ± 0.17 | 0.7 ± 0.26 |
Monocytes (%) | 1.8 ± 0.50 | 1.8 ± 0.42 | 1.7 ± 0.57 | 3.0 ± 0.48** |
Basophils (%) | 0.7 ± 0.14 | 0.6 ± 0.09 | 0.4 ± 0.13** | 0.5 ± 0.04* |
Large unstained cells (%) | 1.1 ± 0.33 | 1.1 ± 0.27 | 0.9 ± 0.17 | 2.0 ± 0.75 |
RBC (106/μL) | 8.4 ± 0.24 | 8.2 ± 0.34 | 8.1 ± 0.25 | 8.0 ± 0.43 |
Hematoglobin (g/dL) | 16.4 ± 0.63 | 16.4 ± 0.78 | 16.6 ± 0.63 | 16.5 ± 0.58 |
Hematocrit (%) | 50.6 ± 1.32 | 50.4 ± 1.63 | 50.5 ± 0.98 | 50.2 ± 1.86 |
MCV (fL) | 60.4 ± 1.32 | 61.5 ± 1.46 | 62.2 ± 1.24 | 63.1 ± 2.54 |
MCH (pg) | 19.5 ± 0.50 | 20.1 ± 0.56 | 20.5 ± 0.61 | 20.7 ± 1.1 |
MCHC (g/dL) | 32.3 ± 1.27 | 32.6 ± 0.55 | 33.0 ± 0.65 | 32.9 ± 0.80 |
Platelet (103/μL) | 1038.0 ± 114.18 | 980.0 ± 61.93 | 1015.8 ± 111.26 | 1014.6 ± 74.29 |
Female rats | ||||
WBC (103/μL) | 5.9 ± 1.60 | 7.2 ± 1.06 | 8.6 ± 2.46 | 6.4 ± 1.06 |
Reticulocytes (%) | 2.6 ± 0.52 | 2.6 ± 0.58 | 2.9 ± 0.25 | 2.7 ± 0.67 |
Neutrophils (%) | 10.0 ± 1.90 | 14.8 ± 7.42 | 13.2 ± 6.83 | 7.8 ± 1.71 |
Lymphocytes (%) | 85.7 ± 2.25 | 81.1 ± 7.82 | 83.3 ± 6.74 | 87.9 ± 1.95 |
Eosinophils (%) | 1.0 ± 0.35 | 0.7 ± 0.17 | 0.9 ± 0.25 | 1.2 ± 0.64 |
Monocytes (%) | 1.9 ± 0.41 | 1.7 ± 0.54 | 1.4 ± 0.11 | 1.7 ± 0.50 |
Basophils (%) | 0.4 ± 0.19 | 0.4 ± 0.17 | 0.3 ± 0.16 | 0.4 ± 0.18 |
Large unstained cells (%) | 1.0 ± 0.11 | 1.2 ± 0.18 | 1.0 ± 0.25 | 1.0 ± 0.21 |
RBC (106/μL) | 8.18 ± 0.42 | 8.3 ± 0.45 | 7.8 ± 0.34 | 8.1 ± 0.42 |
Hematoglobin (g/dL) | 16.3 ± 0.87 | 16.1 ± 0.56 | 15.8 ± 0.43 | 16.0 ± 0.68 |
Hematocrit (%) | 48.7 ± 2.36 | 48.6 ± 2.36 | 47.7 ± 1.84 | 47.6 ± 2.15 |
MCV (fL) | 59.6 ± 0.80 | 58.8 ± 1.61 | 60.9 ± 0.92 | 59.2 ± 0.70 |
MCH (pg) | 19.9 ± 0.28 | 19.5 ± 0.74 | 20.2 ± 0.66 | 19.8 ± 0.34 |
MCHC (g/dL) | 33.4 ± 0.59 | 33.2 ± 0.99 | 33.1 ± 0.76 | 33.5 ± 0.41 |
Platelet (103/μL) | 1063.8 ± 47.47 | 1004.6 ± 104.58 | 1142.8 ± 121.17 | 1181.4 ± 182.15 |