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Table 4 Post-infection AA5, 10, 20 oral administration influence on % weight change changes compared to controls

From: Asiatic acid influences parasitaemia reduction and ameliorates malaria anaemia in P. berghei infected Sprague–Dawley male rats

Parameter Post-infection treatment Pre-patent (D 3) Patent/Treatment (D7–12) Post-treatment (D13- 21)
% body weight change NIC 8 ± 1 14.4 ± 6 18.9 ± 6
IC 10.1 ± 5 4 ± 22.3 N/A
CHQ 8.8 ± 1.5 9.4 ± 6 12.2 ± 0.5
5AA 9.3 ± 2.2 14.2 ± 1.0*# 15.5 ± 1.9#
10AA 8 ± 1 13.7 ± 1* 17.3 ± 0.8#
20AA 9.5 ± 1 11.5 ± 1.9* 13.1 ± 0.2
  1. NIC is non-infected treated control, IC is infected non-treated control and CHQ is chloroquine control (30 mg/kg). Values are presented as means ± SEM, (n = 6 in each group). *, #p < 0.05 by comparison with IC and 30CHQ groups, respectively. NIC non infected treated control, IC infected control, CHQ chloroquine, AA asiatic acid