Asiatic acid influences parasitaemia reduction and ameliorates malaria anaemia in P. berghei infected Sprague–Dawley male rats

Table 4 Post-infection AA5, 10, 20 oral administration influence on % weight change changes compared to controls

Parameter	Post-infection treatment	Pre-patent (D 3)	Patent/Treatment (D7–12)	Post-treatment (D13- 21)
% body weight change	NIC	8 ± 1	14.4 ± 6	18.9 ± 6
	IC	10.1 ± 5	4 ± 22.3	N/A
	CHQ	8.8 ± 1.5	9.4 ± 6	12.2 ± 0.5
	5AA	9.3 ± 2.2	14.2 ± 1.0*#	15.5 ± 1.9#
	10AA	8 ± 1	13.7 ± 1*	17.3 ± 0.8#
	20AA	9.5 ± 1	11.5 ± 1.9*	13.1 ± 0.2

NIC is non-infected treated control, IC is infected non-treated control and CHQ is chloroquine control (30 mg/kg). Values are presented as means ± SEM, (n = 6 in each group). *, #p < 0.05 by comparison with IC and 30CHQ groups, respectively. NIC non infected treated control, IC infected control, CHQ chloroquine, AA asiatic acid

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