Asiatic acid influences parasitaemia reduction and ameliorates malaria anaemia in P. berghei infected Sprague–Dawley male rats

Table 3 Post-infection AA5, 10, 20 oral administration influence on water intake changes compared to controls

Parameter	Post-infection treatment	Pre-patent (D 3)	Patent/Treatment (D7–12)	Post-treatment (D13- 21)
Water intake (mL/100 g)	NIC	14.3 ± 1.0	15.5 ± 1.3	15.2 ± 0.9
	IC	15.5 ± 1.3	8.4 ± 1.7	N/A
	CHQ	14.2 ± 1.2	10.5 ± 1.7	12 ± 1.2
	5AA	15 ± 3	12.7 ± 1*#	14.8 ± 1.9#
	10AA	15.8 ± 0.8	14.2 ± 0.9*#	15.1 ± 1.1#
	20AA	15.2 ± 1	11.6 ± 1.7α*	12.9 ± 1.6

NIC is non-infected treated control, IC is infected non-treated control and CHQ is chloroquine control (30 mg/kg). Values are presented as means ± SEM, (n = 6 in each group). α,*,#p < 0.05 by comparison with NIC, IC, 30CHQ groups, respectively. NIC non infected treated control, IC infected control, CHQ chloroquine, AA asiatic acid

ISSN: 2662-7671