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Table 3 Post-infection AA5, 10, 20 oral administration influence on water intake changes compared to controls

From: Asiatic acid influences parasitaemia reduction and ameliorates malaria anaemia in P. berghei infected Sprague–Dawley male rats

Parameter Post-infection treatment Pre-patent (D 3) Patent/Treatment (D7–12) Post-treatment (D13- 21)
Water intake (mL/100 g) NIC 14.3 ± 1.0 15.5 ± 1.3 15.2 ± 0.9
IC 15.5 ± 1.3 8.4 ± 1.7 N/A
CHQ 14.2 ± 1.2 10.5 ± 1.7 12 ± 1.2
5AA 15 ± 3 12.7 ± 1*# 14.8 ± 1.9#
10AA 15.8 ± 0.8 14.2 ± 0.9*# 15.1 ± 1.1#
20AA 15.2 ± 1 11.6 ± 1.7α* 12.9 ± 1.6
  1. NIC is non-infected treated control, IC is infected non-treated control and CHQ is chloroquine control (30 mg/kg). Values are presented as means ± SEM, (n = 6 in each group). α,*,#p < 0.05 by comparison with NIC, IC, 30CHQ groups, respectively. NIC non infected treated control, IC infected control, CHQ chloroquine, AA asiatic acid