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Table 1 Cytotoxicity of oligostilbenoid compounds isolated from Dryobalanops towards cancer cell lines and non-tumorigenic cell lines at 72 h reflected by the IC50 values as determined by MTT assay

From: Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231

  IC50 (μM)
Compound Flexuosol A Nepalensinol E Laevifonol Ampelopsin F Ampelopsin E Malaysianol A Malaysianol D Tamoxifen (Positive control) Doxorubicin
Cell line
MDA-MB-231 27.5 ± 3.54 >30 >30 >30 14.5 ± 0.71 23 ± 4.24 >30 7 ± 1.41 0.4 ± 0
MCF-7 >30 >30 >30 >30 29.5 ± 0.71 >30 >30 11.5 ± 3.54 0.21 ± 0.27
HT-29 >30 >30 >30 >30 >30 N/A N/A N/A N/A
A-549 >30 >30 >30 >30 >30 N/A N/A N/A N/A
HeLa >30 >30 >30 >30 >30 N/A N/A N/A N/A
3T3 >30 >30 >30 >30 >30 N/A N/A N/A N/A
MCF10A >30 N/A N/A N/A >30 >30 >30 N/A >10
  1. Each data point represents the mean of two independent experiments ± SD