Filaricidal activities on Onchocerca ochengi and Loa loa, toxicity and phytochemical screening of extracts of Tragia benthami and Piper umbellatum

Table 2 Mean percent activity of crude extracts on Onchocerca ochengi adult worms and mf in primary screens

Plant or control	Extract code	Concentration tested	Activity on O. ochengi male (%)	Activity on O. ochengi female (%)	Activity on O. ochengi mf (%)
Tragia benthami	TBLhex	500 μg/mL	100	91.25	75
	TBLmc	500 μg/mL	100	87.5	100
	TBLmet	500 μg/mL	100	56.25	100
	TBRhex	500 μg/mL	100	100	100
	TBRmc	500 μg/mL	100	93.75	100
	TBRmet	500 μg/mL	100	12.5	100
Piper unbellatum	PULhex	500 μg/mL	100	100	100
	PULmc	500 μg/mL	100	100	100
	PULmet	500 μg/mL	100	100	100
	PURhex	500 μg/mL	100	100	100
	PURmc	500 μg/mL	100	100	100
	PURmet	500 μg/mL	100	100	100
	PUShex	500 μg/mL	100	100	100
	PUSmc	500 μg/mL	100	100	100
Negative control	NA	2 % DMSO	0	0	0
Auranofin (Positive control)	NA	10 μM	100	100	100

TBL Tragia benthami leaves, TBR Tragia benthami roots, PUL Piper umbellatum leaves, PUR Piper umbellatum roots, PUS Piper umbellatum seeds, hex hexane, mc methylene chloride, met methanol, NA not applicable

ISSN: 2662-7671