Skip to main content
Fig. 9 | BMC Complementary and Alternative Medicine

Fig. 9

From: Multiple cellular effects of leaf extracts from Parinari curatellifolia

Fig. 9

Proposed mechanism of action of effect of Parinari curatellifolia water extract on nitric oxide production in RAW 264.7 murine macrophage cells. Lipopolysaccharide (LPS) activates a G-protein cascade that leads to the dissociation of NFKβ from its inhibitor molecule IKβ. The dissociation of NFKβ allows nuclear translocation of the transcription factor to activate the expression of iNOS. iNOS catalyses the breakdown of L-arginine to citrulline with NO as a by-product. P. curatellifolia water extract was able to scavenge NO radicals which could reduce its effect on its target cells

Back to article page