Anticonvulsant effects of iridoid glycosides fraction purified from Feretia apodanthera Del. (Rubiaceae) in experimental mice models of generalized tonic-clonic seizures

Table 3 Effects of IGEFA on lipid peroxidation product, brain reduced glutathione and brain GABA content in whole mice brain on pentylentetrazole-induced kindling in mice

Treatments	Dose (mg/kg)	Brain lipid peroxidation, MDA (nmol/g-wet tissue)	Brain reduced glutathione, GSH (μg/g-wet tissue)	Brain GABA level (μg/g-wet tissue)
Vehicle + Saline	– + –	142.79 ± 16.24	196.24 ± 12.31	398.51 ± 12.42
Vehicle + PTZ	– + 30	454.62 ± 18.41	101.17 ± 14.24	297.38 ± 13.59
IGEFA + PTZ	15 + 30	362.24 ± 16.26*	132.15 ± 13.15*	398.53 ± 18.37
IGEFA + PTZ	30 + 30	195.13 ± 19.15**	158.47 ± 12.41*	397.62 ± 13.85
IGEFA + PTZ	60 + 30	178.47 ± 17.39**	185.75 ± 14.53**	435.49 ± 17.52*
IGEFA + PTZ	90 + 30	156.19 ± 16.43***	192.25 ± 16.24**	455.13 ± 16.38**
SVA + PTZ	300 + 30	149.17 ± 19.75***	195.62 ± 14.46**	452.36 ± 15.46**
SVA + Saline	300 + –	147.36 ± 17.15***	197.37 ± 19.31**	462.37 ± 17.25**
IGEFA + Saline	90 + –	152.61 ± 17.35***	199.21 ± 14.19**	471.41 ± 14.33**

Results are expressed as mean ± S.E.M., for 6 animals. Data were analysis by two-way ANOVA, followed by Newman-Keuls post hoc test
MDA malondialdehyde, GSH glutathione, GABA gamma-aminobutyric acid, SVA sodium valproate, IGEFA iridoid glycosides extracts of Feretia apodenthera
*P < 0.05, **P < 0.01, ***P < 0.001, significantly different compared to the vehicle-treated PTZ mice

ISSN: 2662-7671