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Table 3 Effects of IGEFA on lipid peroxidation product, brain reduced glutathione and brain GABA content in whole mice brain on pentylentetrazole-induced kindling in mice

From: Anticonvulsant effects of iridoid glycosides fraction purified from Feretia apodanthera Del. (Rubiaceae) in experimental mice models of generalized tonic-clonic seizures

Treatments Dose (mg/kg) Brain lipid peroxidation, MDA (nmol/g-wet tissue) Brain reduced glutathione, GSH (μg/g-wet tissue) Brain GABA level (μg/g-wet tissue)
Vehicle + Saline – + – 142.79 ± 16.24 196.24 ± 12.31 398.51 ± 12.42
Vehicle + PTZ – + 30 454.62 ± 18.41 101.17 ± 14.24 297.38 ± 13.59
IGEFA + PTZ 15 + 30 362.24 ± 16.26* 132.15 ± 13.15* 398.53 ± 18.37
IGEFA + PTZ 30 + 30 195.13 ± 19.15** 158.47 ± 12.41* 397.62 ± 13.85
IGEFA + PTZ 60 + 30 178.47 ± 17.39** 185.75 ± 14.53** 435.49 ± 17.52*
IGEFA + PTZ 90 + 30 156.19 ± 16.43*** 192.25 ± 16.24** 455.13 ± 16.38**
SVA + PTZ 300 + 30 149.17 ± 19.75*** 195.62 ± 14.46** 452.36 ± 15.46**
SVA + Saline 300 + – 147.36 ± 17.15*** 197.37 ± 19.31** 462.37 ± 17.25**
IGEFA + Saline 90 + – 152.61 ± 17.35*** 199.21 ± 14.19** 471.41 ± 14.33**
  1. Results are expressed as mean ± S.E.M., for 6 animals. Data were analysis by two-way ANOVA, followed by Newman-Keuls post hoc test
  2. MDA malondialdehyde, GSH glutathione, GABA gamma-aminobutyric acid, SVA sodium valproate, IGEFA iridoid glycosides extracts of Feretia apodenthera
  3. *P < 0.05, **P < 0.01, ***P < 0.001, significantly different compared to the vehicle-treated PTZ mice