Table 2 Effects of IGEFA or sodium valproate on pentylentetrazol-induced kindling in mice

Vehicle + Saline

– + –

–

–

–

–

–

–

–

Vehicle + PTZ

– + 30

30.00 ± 1.65

64.32 ± 2.45

45.45 ± 8.55

61.83 ± 8.61

185.45 ± 15.55

19.48 ± 1.32

4.00 ± 0.00

IGEFA + PTZ

15 + 30

32.21 ± 2.45

28.23 ± 2.14**

68.54 ± 5.25

75.16 ± 7.61

252.27 ± 24.14*

14.12 ± 1.25

2.33 ± 0.45*

IGEFA + PTZ

30 + 30

44.13 ± 2.28*

18.48 ± 2.13**

85.48 ± 4.47

185.21 ± 9.15***

324.15 ± 27.12***

8.24 ± 0.16**

2.16 ± 0.27*

IGEFA + PTZ

60 + 30

44.36 ± 2.32*

14.25 ± 2.34**

126.53 ± 8.15***

285.20 ± 7.62***

388.22 ± 35.26***

4.86 ± 0.24***

1.83 ± 0.28**

IGEFA + PTZ

90 + 30

43.72 ± 2.48*

8.45 ± 1.22***

173.62 ± 9.34***

371.52 ± 6.27***

495.48 ± 57.41***

3.29 ± 0.23***

1.33 ± 0.44**

SVA + PTZ

300 + 30

43.58 ± 2.34**

7.24 ± 1.56***

157.47 ± 8.52***

245.57 ± 6.45***

582.54 ± 48.36***

2.27 ± 0.15***

1.16 ± 0.27**

SVA + Saline

300 + –

–

–

–

–

–

–

–

IGEFA + Saline

90 + –

–

–

–

–

–

–

–