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Table 2 Effects of IGEFA or sodium valproate on pentylentetrazol-induced kindling in mice

From: Anticonvulsant effects of iridoid glycosides fraction purified from Feretia apodanthera Del. (Rubiaceae) in experimental mice models of generalized tonic-clonic seizures

Treatments Dose (mg/kg)   Behavioural seizure  
kindling development (day) Number Duration (s) Seizure mean stage
Myoclonic jerks Myoclonic jerks latency Onset of clonic seizures Latency to generalized clonic-tonic seizures Duration of generalized clonic-tonic seizures
Vehicle + Saline – + –
Vehicle + PTZ – + 30 30.00 ± 1.65 64.32 ± 2.45 45.45 ± 8.55 61.83 ± 8.61 185.45 ± 15.55 19.48 ± 1.32 4.00 ± 0.00
IGEFA + PTZ 15 + 30 32.21 ± 2.45 28.23 ± 2.14** 68.54 ± 5.25 75.16 ± 7.61 252.27 ± 24.14* 14.12 ± 1.25 2.33 ± 0.45*
IGEFA + PTZ 30 + 30 44.13 ± 2.28* 18.48 ± 2.13** 85.48 ± 4.47 185.21 ± 9.15*** 324.15 ± 27.12*** 8.24 ± 0.16** 2.16 ± 0.27*
IGEFA + PTZ 60 + 30 44.36 ± 2.32* 14.25 ± 2.34** 126.53 ± 8.15*** 285.20 ± 7.62*** 388.22 ± 35.26*** 4.86 ± 0.24*** 1.83 ± 0.28**
IGEFA + PTZ 90 + 30 43.72 ± 2.48* 8.45 ± 1.22*** 173.62 ± 9.34*** 371.52 ± 6.27*** 495.48 ± 57.41*** 3.29 ± 0.23*** 1.33 ± 0.44**
SVA + PTZ 300 + 30 43.58 ± 2.34** 7.24 ± 1.56*** 157.47 ± 8.52*** 245.57 ± 6.45*** 582.54 ± 48.36*** 2.27 ± 0.15*** 1.16 ± 0.27**
SVA + Saline 300 + –
IGEFA + Saline 90 + –
  1. Results are expressed as mean ± S.E.M., for 6 animals. Data were analysis by two-way ANOVA, followed by Newman-Keuls post hoc test
  2. PTZ pentylenetetrazol, SVA sodium valproate, IGEFA iridoid glycosides extracts of Feretia apodenthera
  3. *P < 0.05, **P < 0.01, ***P < 0.001, significantly different compared to the vehicle-treated pentylentetrazole mice