Table 1 Effects of IGEFA or diazepam on bicuculline-induced motor seizures in mice

Vehicle + Saline

– + –

–

–

–

–

–

–

Vehicle + Bic

– + 2.7

2.35 ± 0.21

6.15 ± 1.12

5.32 ± 1.47

69.32 ± 1.38

24.16 ± 1.14

8/8

IGEFA + Bic

15 + 2.7

4.12 ± 0.27

11.16 ± 1.13

4.21 ± 1.15

19.12 ± 1.54*

14.57 ± 1.26

1/8***

IGEFA + Bic

30 + 2.7

6.15 ± 1.26*

13.53 ± 1.04*

3.49 ± 1.26

16.35 ± 1.29*

12.32 ± 1.39*

1/8***

IGEFA + Bic

60 + 2.7

7.21 ± 1.23*

16.17 ± 1.18*

3.15 ± 1.13

12.49 ± 1.17*

11.49 ± 1.81*

0/8***

IGEFA + Bic

90 + 2.7

7.49 ± 1.49*

18.32 ± 1.36*

2.34 ± 1.52*

11.26 ± 1.27**

11.52 ± 1.16*

0/8***

Diazepam + Bic

5 + 2.7

8.27 ± 1.28**

21.42 ± 2.19**

1.26 ± 1.24*

11.32 ± 1.45**

10.26 ± 1.28*

0/8***