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Table 1 Effects of IGEFA or diazepam on bicuculline-induced motor seizures in mice

From: Anticonvulsant effects of iridoid glycosides fraction purified from Feretia apodanthera Del. (Rubiaceae) in experimental mice models of generalized tonic-clonic seizures

Treatments Dose (mg/kg) Behavioural seizures Mortality
   Onset (min) Duration (min) Number of motor seizures  
   Tonus Clonus Tonus Clonus   
Vehicle + Saline – + –
Vehicle + Bic – + 2.7 2.35 ± 0.21 6.15 ± 1.12 5.32 ± 1.47 69.32 ± 1.38 24.16 ± 1.14 8/8
IGEFA + Bic 15 + 2.7 4.12 ± 0.27 11.16 ± 1.13 4.21 ± 1.15 19.12 ± 1.54* 14.57 ± 1.26 1/8***
IGEFA + Bic 30 + 2.7 6.15 ± 1.26* 13.53 ± 1.04* 3.49 ± 1.26 16.35 ± 1.29* 12.32 ± 1.39* 1/8***
IGEFA + Bic 60 + 2.7 7.21 ± 1.23* 16.17 ± 1.18* 3.15 ± 1.13 12.49 ± 1.17* 11.49 ± 1.81* 0/8***
IGEFA + Bic 90 + 2.7 7.49 ± 1.49* 18.32 ± 1.36* 2.34 ± 1.52* 11.26 ± 1.27** 11.52 ± 1.16* 0/8***
Diazepam + Bic 5 + 2.7 8.27 ± 1.28** 21.42 ± 2.19** 1.26 ± 1.24* 11.32 ± 1.45** 10.26 ± 1.28* 0/8***
  1. Results are expressed as mean ± S.E.M., for 8 animals, bicuculline (2.7 mg/kg; s.c.) was injected intraperitonealy in mice
  2. Bic bicuculline, IGEFA iridoid glycosides extracts of Feretia apodenthera
  3. *P < 0.05, **P < 0.01, ***P < 0.001 significantly different compared to the vehicle, data were analysed by two-way ANOVA, followed by Newman-Keuls post hoc test