|
Treatments
|
Dose (mg/kg)
|
Behavioural seizures
|
Mortality
|
|---|
| | |
Onset (min)
|
Duration (min)
|
Number of motor seizures
| |
|---|
| | |
Tonus
|
Clonus
|
Tonus
|
Clonus
| | |
|---|
|
Vehicle + Saline
|
– + –
|
–
|
–
|
–
|
–
|
–
|
–
|
|
Vehicle + Bic
|
– + 2.7
|
2.35 ± 0.21
|
6.15 ± 1.12
|
5.32 ± 1.47
|
69.32 ± 1.38
|
24.16 ± 1.14
|
8/8
|
|
IGEFA + Bic
|
15 + 2.7
|
4.12 ± 0.27
|
11.16 ± 1.13
|
4.21 ± 1.15
|
19.12 ± 1.54*
|
14.57 ± 1.26
|
1/8***
|
|
IGEFA + Bic
|
30 + 2.7
|
6.15 ± 1.26*
|
13.53 ± 1.04*
|
3.49 ± 1.26
|
16.35 ± 1.29*
|
12.32 ± 1.39*
|
1/8***
|
|
IGEFA + Bic
|
60 + 2.7
|
7.21 ± 1.23*
|
16.17 ± 1.18*
|
3.15 ± 1.13
|
12.49 ± 1.17*
|
11.49 ± 1.81*
|
0/8***
|
|
IGEFA + Bic
|
90 + 2.7
|
7.49 ± 1.49*
|
18.32 ± 1.36*
|
2.34 ± 1.52*
|
11.26 ± 1.27**
|
11.52 ± 1.16*
|
0/8***
|
|
Diazepam + Bic
|
5 + 2.7
|
8.27 ± 1.28**
|
21.42 ± 2.19**
|
1.26 ± 1.24*
|
11.32 ± 1.45**
|
10.26 ± 1.28*
|
0/8***
|
- Results are expressed as mean ± S.E.M., for 8 animals, bicuculline (2.7 mg/kg; s.c.) was injected intraperitonealy in mice
-
Bic bicuculline, IGEFA iridoid glycosides extracts of Feretia apodenthera
- *P < 0.05, **P < 0.01, ***P < 0.001 significantly different compared to the vehicle, data were analysed by two-way ANOVA, followed by Newman-Keuls post hoc test
