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Table 3 Changes in the levels of various enzymatic and biochemical parameters of the culture supernatants of the experimental groups. Data represented as mean ± SD of six observations

From: Haloalkane induced hepatic insult in murine model: amelioration by Oleander through antioxidant and anti-inflammatory activities, an in vitro and in vivo study

Parameters (unit)

Control

CCl4

Silymarin

NOSE low

NOSE high

NORE low

NORE high

ACP (K.A.)

0.71 ± 0.10

1.74 ± 0.11***

1.17 ± 0.16* b

1.58 ± 0.12*** d

1.48 ± 0.08*** c

1.61 ± 0.15** d

1.40 ± 0.16** c

ALP (K.A.)

3.09 ± 0.11

7.51 ± 0.33***

4.13 ± 0.25** a

6.79 ± 0.24*** c

5.91 ± 0.27*** b

6.99 ± 0.37*** d

6.09 ± 0.50*** c

AST (U/ml)

14.87 ± 0.72

44.49 ± 0.75***

16.39 ± 1.41NS a

43.86 ± 2.60*** d

36.32 ± 1.21*** a

38.06 ± 3.76*** c

29.53 ± 3.22** b

ALT (U/ml)

5.81 ± 0.15

27.55 ± 0.52***

10.57 ± 0.29*** a

26.33 ± 1.29*** d

22.17 ± 2.40*** c

24.47 ± 1.82*** c

20.77 ± 1.63*** b

GGT (U/l)

0.59 ± 0.04

0.78 ± 0.02**

0.58 ± 0.01NS a

0.77 ± 0.01** d

0.71 ± 0.03* d

0.74 ± 0.00** d

0.72 ± 0.01** c

Bilirubin (mg/dl)

0.13 ± 0.00

0.53 ± 0.05***

0.17 ± 0.00** a

0.56 ± 0.14** b

0.40 ± 0.02*** b

0.465 ± 0.02*** d

0.43 ± 0.02** d

Protein (g/dl)

6.48 ± 0.75

5.3 ± 0.26NS

5.7 ± 0.42 NS d

5.61 ± 0.23 NS d

6.05 ± 0.15 NS c

5.77 ± 0.12NS c

6.02 ± 0.21NS c

LDH (U/l)

35.94 ± 29.66

181.33 ± 11.24**

94.16 ± 7.34* a

138.59 ± 14.05** c

105.00 ± 10.02* a

144.40 ± 11.49** c

114.87 ± 10.53* b

  1. NSp = non-significant (p > 0.05), *p < 0.05, **p < 0.01 and ***p < 0.001 vs control
  2. dp = non-significant (p > 0.05), c p < 0.05, b p < 0.01 and a p < 0.001 vs CCl4 group