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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Haloalkane induced hepatic insult in murine model: amelioration by Oleander through antioxidant and anti-inflammatory activities, an in vitro and in vivo study

Fig. 4

Photomicrographs (400×) of the histopathological examinations of the liver samples of different groups. a Control group liver sampled possessed well packed hepatocytes with intact nucleus (IN) and normal sinusoids (NS). b CCl4 group liver possessed extensive fatty infiltrations (FI), Necrotic hepatocytes (N), prominent signs of inflammation with leukocyte infiltrations (LI), prominent calcification (C) around the congested vesicles (VC) with bile duct proliferations (BdP). c Silymarin group liver samples were characterized with normal sinusoids (NS) and intact nucleus (IN) containing healthy hepatocytes. d NOSE low group demonstrated lower fatty infiltrations (FI), sinusoidal dilations (SD) and leukocyte infiltrations (LI). e NOSE high group resulted in renewal of normal hepatic architecture with several hepatocytes with intact nucleus (IN) and lowered sinusoidal dilations (SD). f NORE low group livers possessed few necrotic (N) cells, fatty infiltrations (FI) and zonal calcification (C) around the portal veins (PV). g NOSE high group showed near to normal hepatic architecture with predominantly intact nucleus (IN) containing normal hepatocytes and undiluted normal sinusoids (NS)

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