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Table 3 Antipyretic activity of Monotheca buxifolia hydro-ethanolic extract (MBHE) in brewer’s yeast induced pyrexia in mice

From: Pharmacological screening of Monotheca buxifolia (Falc.) A. DC. for antinociceptive, anti-inflammatory and antipyretic activities

Treatment

1st h

2nd h

3rd h

4th h

5th h

Group 1

(Brewer’s yeast + Saline)

100.4 ± 0.358

100.5 ± 0.346

100.0 ± 0.335

100.4 ± 0.265

100.5 ± 0.341

Group 2

(Acetaminophen 150 mg/kg)

96.18 ± 0.757***

96.62 ± 0.755***

95.50 ± 1.023***

96.07 ± 0.720***

95.23 ± 0.731***

Group 3

(MBHE 50 mg/kg)

97.93 ± 0.449

98.20 ± 0.634*

98.58 ± 0.838

99.27 ± 0.860

99.88 ± 0.812

Group 4

(MBHE 100 mg/kg)

96.02 ± 0.884***

97.18 ± 0.570**

97.68 ± 0.244*

97.72 ± 0.342*

97.42 ± 0.709*

Group 5

(MBHE 150 mg/kg)

93.70 ± 0.753***

96.93 ± 0.584***

96.48 ± 0.303**

97.33 ± 0.547**

96.35 ± 0.837**

  1. Values are expressed as mean rectal temperature in °F ± SD. ANOVA followed by Dunnett’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001 compared to group 1. n = 6 animals per group